Institutional Repository of Key Laboratory of Mental Health, CAS
The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-State Activity in mPFC | |
Jiesi Wang1; Wei Zhang1,2; Hang Xu1; Bart Ellenbroek3; Jiajie Dai1,2; Li Wang, Chaogan Yan1,2; Chaogan Yan2,4; Weiwen Wang1,2 | |
通讯作者 | Yan, Chaogan(yancg@psych.ac.cn) ; Wang, Weiwen(wangww@psych.ac.cn) |
通讯作者邮箱 | wangww@psych.ac.cn (w.w.) ; yancg@psych.ac.cn (c.y.) |
心理所单位排序 | 1 |
摘要 | Early-life stress can lead to sustained alterations in regional resting-state brain functions, but the underlying molecular mechanism remains unclear. Stress can also induce sustained changes in epigenetic modifications across brain regions, which are not limited to a few genes; rather, they often tend to produce global levels of change. The functional implication of these changes also remains to be elucidated. We hypothesize that global epigenetic changes may partly modulate the resting-state functions of brain regions to influence behavior. To test this hypothesis, we used an adolescent social stress (ASS) model in mice and examined the relationship between epigenetic modifications and regional resting-state brain activity using resting-state functional magnetic resonance imaging (rs-fMRI). The results showed that, compared to the control mice, the stressed mice showed increased anxiety and social avoidance behaviors and greater levels of dimethylation of histone H3 at lysine 9 (H3K9me2) in the medial prefrontal cortex (mPFC). In addition, the resting-state activity represented by the amplitude of low-frequency fluctuation (ALFF) was significantly lower in the mPFC of stressed mice. To verify the relationship of H3K9me2 and ALFF, the specific inhibition of H3Kme2 was performed by using the drug UNC0642, which reversed the anxiety behavior induced by ASS and significantly increase the ALFF value of mPFC in both normal and ASS animals. Our study is the first to report an association between histone modifications and rs-fMRI findings, providing a new perspective for understanding of the significance of regional brain epigenetic changes and a possible molecular explanation for rs-fMRI findings. |
2023 | |
语种 | 英语 |
DOI | 10.34133/research.0264 |
发表期刊 | Research |
ISSN | 2096-5168 |
卷号 | 6期号:6页码:12 |
期刊论文类型 | 实证研究 |
收录类别 | SSCI |
资助项目 | National Natural Science Foundation of China[82071517] ; National Natural Science Foundation of China[U21A20364] ; National Natural Science Foundation of China[31771217] ; National Natural Science Foundation of China[31900731] ; National Key R&D Program of China[2017YFE0126500] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4115CX] |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
WOS关键词 | ACETYLATION ; EPIGENETICS ; G9A ; HIPPOCAMPUS ; NETWORK ; CORTEX ; GENES |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:001121584800002 |
资助机构 | National Natural Science Foundation of China ; National Key R&D Program of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46274 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. 2.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. 3.School of Psychology, Victoria University of Wellington, Kelburn, Wellington 6012, New Zealand 4.CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. |
第一作者单位 | 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Jiesi Wang,Wei Zhang,Hang Xu,et al. The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-State Activity in mPFC[J]. Research,2023,6(6):12. |
APA | Jiesi Wang.,Wei Zhang.,Hang Xu.,Bart Ellenbroek.,Jiajie Dai.,...&Weiwen Wang.(2023).The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-State Activity in mPFC.Research,6(6),12. |
MLA | Jiesi Wang,et al."The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-State Activity in mPFC".Research 6.6(2023):12. |
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