Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors

doi:10.1007/s40519-023-01617-5

PSYCH OpenIR

	Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors
	Wang, Jia-ni 1; Wang, Miao 2; Wu, Guo-wei 3; Li, Wei-hua 1; Lv, Zi-ling 4,5,6; Chen, Qian 1; Yang, Zheng-han 1; Li, Xiao-hong 4,5,6; Wang, Zhen-chang 1; Li, Zhan-jiang 4,5,6; Zhang, Peng 1; Tang, Li-rong 4,5,6
通讯作者	Li, Zhan-jiang(li_zhanjiang@vip.sina.com) ; Zhang, Peng(zpqz1021@foxmail.com) ; Tang, Li-rong(tangl_@163.com)
摘要	PurposeBulimia nervosa (BN) is characterized by recurrent binge-eating episodes and inappropriate compensatory behaviors. This study investigated alterations in resting-state surface-based neural activity in BN patients and explored correlations between brain activity and eating behavior.MethodsA total of 26 BN patients and 28 healthy controls were enrolled. Indirect measurement of cerebral cortical activity and functional connectivity (FC) analyses were performed in Surfstat. A principal component analysis (PCA) model was used to capture the commonalities within the behavioral questionnaires from the BN group.ResultsCompared with the healthy control group, the BN group showed decreased surface-based two-dimensional regional homogeneity in the right superior parietal lobule (SPL). Additionally, the BN group showed decreased FC between the right SPL and the bilateral lingual gyrus and increased FC between the right SPL and the left caudate nucleus and right putamen. In the FC-behavior association analysis, the second principal component (PC2) was negatively correlated with FC between the right SPL and the left caudate nucleus. The third principal component (PC3) was negatively correlated with FC between the right SPL and the left lingual gyrus and positively correlated with FC between the right SPL and the right lingual gyrus.ConclusionWe revealed that the right SPL undergoes reorganization with respect to specific brain regions at the whole-brain level in BN. In addition, our results suggest a correlation between brain reorganization and maladaptive eating behavior. These findings may provide useful information to better understand the neural mechanisms of BN.Level of evidenceV, descriptive study.
关键词	Bulimia nervosa Surface-based regional homogeneity Functional connectivity Principal component analysis Eating behavior Visual information
	2023-10-30
语种	英语
DOI	10.1007/s40519-023-01617-5
发表期刊	EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
ISSN	1124-4909
卷号	28 期号:1 页码:14
收录类别	SCI
资助项目	This work was supported by Grant No. 82001790 from the National Natural Science Foundation of China, Grant No. QML20191902 from the Beijing Hospitals Authority Youth Programme, seed project No. YYZZ201917 from Beijing Friendship Hospital, Capital Medical U[82001790] ; National Natural Science Foundation of China[QML20191902] ; Beijing Hospitals Authority Youth Programme[YYZZ201917] ; Beijing Friendship Hospital, Capital Medical University[2021-135] ; Beijing key Clinical Discipline Funding ; Beijing Key Laboratory of Mental Disorders[2021JSJB03]
出版者	SPRINGER
WOS关键词	SUPERIOR PARIETAL CORTEX ; PSYCHOMETRIC PROPERTIES ; CHINESE VERSION ; DISORDERS ; WOMEN ; 1ST-EPISODE ; DEPRESSION ; ANATOMY ; NAIVE
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:001088939600001
资助机构	This work was supported by Grant No. 82001790 from the National Natural Science Foundation of China, Grant No. QML20191902 from the Beijing Hospitals Authority Youth Programme, seed project No. YYZZ201917 from Beijing Friendship Hospital, Capital Medical U ; National Natural Science Foundation of China ; Beijing Hospitals Authority Youth Programme ; Beijing Friendship Hospital, Capital Medical University ; Beijing key Clinical Discipline Funding ; Beijing Key Laboratory of Mental Disorders
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/46316
通讯作者	Li, Zhan-jiang; Zhang, Peng; Tang, Li-rong
作者单位	1.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, 95 Yong An Rd, Beijing, Peoples R China 2.Chinese Inst Brain Res, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 4.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 5.Natl Clin Res Ctr Mental Disorders, 5 Ankang Hutong, Beijing, Peoples R China 6.Beijing Key Lab Mental Disorders, 5 Ankang Hutong, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jia-ni,Wang, Miao,Wu, Guo-wei,et al. Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors[J]. EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY,2023,28(1):14.
APA	Wang, Jia-ni.,Wang, Miao.,Wu, Guo-wei.,Li, Wei-hua.,Lv, Zi-ling.,...&Tang, Li-rong.(2023).Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors.EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY,28(1),14.
MLA	Wang, Jia-ni,et al."Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors".EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY 28.1(2023):14.