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Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naive young major depressive disorder patients with comorbid anxiety | |
Ye, Gang1,2; Yuan, Ying2; Li, Zhe2; Yue, Yan1,2; Wu, Yuxuan1,2; Yang, Ruchang1,2; Wang, Haitao3; Wu, Siqi2,3; Zhou, Yue2,4; Zhao, Xueli2; Lv, Xiaoli2; Yuan, Nian2; Li, Ronghua2; Zhang, Guangya2; Du, Xiangdong2; Zhang, Xiangyang5 | |
第一作者 | GangYe |
通讯作者邮箱 | xiangdong-du@ 163.com (du, xiangdong) ; zhangxy@ psych.ac.cn. (zhang, xiangyang) |
心理所单位排序 | 5 |
摘要 | This study aimed to explore sex differences in the relationship between thyroid function indicators and suicide attempts in first-episode and drug-naive young major depressive disorder (MDD) patients with comorbid anxiety (MDA). A total of 917 MDD patients (aged 18-35 years) were recruited. The Hamilton depression rating scale (HAMD-17), Hamilton anxiety rating scale (HAMA), positive and negative syndrome scale (PANSS) positive subscale and clinical global impression of severity scale (CGI-S) were used. 467 patients were classified as MDA. The prevalence of suicide attempts was 31.3% in MDA patients, which was significantly higher than that (7.3%) in MDD patients without anxiety. Compared with MDA patients without suicide attempts, MDA patients with suicide attempts were older, had a later age of onset, higher HAMD-17, HAMA, and PANSS positive symptom subscale scores, as well as higher TSH, TgAb and TPOAb levels. For male patients, TSH and TPOAb levels were independently associated with suicide attempts. For female patients, HAMA, PANSS positive symptom scores, CGI-S score and TPOAb levels were independently associated with suicide attempts. Our results suggest that the indicators of thyroid function which can predict suicide attempts in male and female MDA patients have sex differences. |
2023-08-22 | |
语种 | 英语 |
DOI | 10.1038/s41598-023-40948-2 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 13期号:1页码:9 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
出版者 | NATURE PORTFOLIO |
WOS关键词 | GENDER DIFFERENCES ; RISK-FACTORS ; ADOLESCENTS ; IDEATION ; INDIVIDUALS ; PREVALENCE ; BEHAVIORS ; ADULTS |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:001052937600052 |
WOS分区 | Q2 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46330 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Du, Xiangdong; Zhang, Xiangyang |
作者单位 | 1.Soochow Univ, Suzhou Med Coll, Suzhou, Peoples R China 2.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, 11 Guangqian Rd, Suzhou 215137, Jiangsu, Peoples R China 3.North China Univ Sci & Technol, Sch Psychol & Mental Hlth, Tangshan, Peoples R China 4.Xuzhou Med Univ, Xuzhou, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Ye, Gang,Yuan, Ying,Li, Zhe,et al. Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naive young major depressive disorder patients with comorbid anxiety[J]. SCIENTIFIC REPORTS,2023,13(1):9. |
APA | Ye, Gang.,Yuan, Ying.,Li, Zhe.,Yue, Yan.,Wu, Yuxuan.,...&Zhang, Xiangyang.(2023).Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naive young major depressive disorder patients with comorbid anxiety.SCIENTIFIC REPORTS,13(1),9. |
MLA | Ye, Gang,et al."Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naive young major depressive disorder patients with comorbid anxiety".SCIENTIFIC REPORTS 13.1(2023):9. |
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Sex-differential ass(961KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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