Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder

doi:10.1007/s00406-023-01698-4

PSYCH OpenIR

	Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder
	Shang, ZhaoXuan 2; Lang, XiaoE 3; Wang, Jikun 2; Zhang, XiangYang 1
通讯作者	Wang, Jikun(jkwang@psy.ecnu.edu.cn) ; Zhang, XiangYang(zhangxy@psych.ac.cn)
摘要	This study investigates the relationship between psychotic symptoms and suicide attempts in young first-episode, drug-naive Chinese Han outpatients diagnosed with Major Depressive Disorder (MDD). The prevalence of Psychotic Major Depressive Disorder (PMD) was found to be 8.3% among the enrolled MDD patients. The study assessed 1289 participants using various scales to evaluate the severity of clinical symptoms, including the CGI-S, the HAMD, the HAMA, and the PANSS positive subscale. Additionally, thyroid hormone and glucolipid metabolism indicators were examined. The findings indicate that among patients with PMD, 41.12% had recent suicide attempts, while 6.54% had previous suicide attempts. Patients who recently attempted suicide exhibited higher scores on the HAMA and CGI scales, along with elevated serum levels of Thyroid-Stimulating Hormone (TSH) and total cholesterol (TC), as well as higher systolic and diastolic blood pressure. Notably, TSH levels independently correlated with recent suicide attempts in PMD patients, with an impressive area under the receiver operating characteristic curve (AUROC) of 0.923. Furthermore, the subgroup of patients with previous suicide attempts displayed longer illness duration and higher HAMD scores. Duration of illness and HAMD were found to be independently associated with previous suicide attempts among PMD patients, with a combined predictive effect showing a robust AUROC of 0.910. In conclusion, this study highlights the significant prevalence of recent and previous suicide attempts among young Chinese Han outpatients with PMD. The identification of risk factors, especially the link between TSH levels and recent suicide attempts, offers valuable insights for clinicians to develop targeted interventions and preventive strategies for this vulnerable patient population.
关键词	Major depressive disorder Psychotic symptoms Suicide attempts Prevalence Risk factors
	2023-10-25
语种	en
DOI	10.1007/s00406-023-01698-4
发表期刊	EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
ISSN	0940-1334
页码	10
收录类别	SCI
出版者	SPRINGER HEIDELBERG
WOS关键词	DELUSIONAL DEPRESSION ; THYROID-DYSFUNCTION ; EXPERIENCES ; IDEATION ; INDIVIDUALS ; THYROTROPIN ; ASSOCIATION ; DIAGNOSIS ; SYMPTOMS
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:001086821700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/46334
通讯作者	Wang, Jikun; Zhang, XiangYang
作者单位	1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.East China Normal Univ, Dept Psychol & Cognit Sci, Shanghai, Peoples R China 3.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China
推荐引用方式 GB/T 7714	Shang, ZhaoXuan,Lang, XiaoE,Wang, Jikun,et al. Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2023:10.
APA	Shang, ZhaoXuan,Lang, XiaoE,Wang, Jikun,&Zhang, XiangYang.(2023).Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,10.
MLA	Shang, ZhaoXuan,et al."Prevalence and risk factors of suicide attempts in young, first-episode and drug-naive Chinese Han outpatients with psychotic major depressive disorder".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023):10.