| Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population | |
Xue, Hui1,2; Xu, Xiaojun3; Yan, Zhihan4,5; Cheng, Jingliang6; Zhang, Longjiang7; Zhu, Wenzhen8; Cui, Guangbin9,10; Zhang, Quan11 ; Qiu, Shijun12; Yao, Zhenwei13; Qin, Wen1,2; Liu, Feng1,2; Liang, Meng14,15; Fu, Jilian1,2; Xu, Qiang1,2; Xu, Jiayuan1,2; Xie, Yingying1,2; Zheng, Peng16; Li, Wei16; Wang, Caihong6; Shen, Wen17; Zhang, Xiaochu18; Xu, Kai19; Zuo, Xi-Nian20,21; Ye, Zhaoxiang22; Yu, Yongqiang23; Xian, Junfang24; Yu, Chunshui1,2,25
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| 通讯作者邮箱 | yuyongqlang@ahmu.edu.cn (y.y) ; cji.xianjunfang@vip.163.com (j.x.) ; chunshuiyu@tmu.edu.cn (c.y) |
| 摘要 | Correlation between blood-oxygen-level-dependent (BOLD) and cerebral blood flow (CBF) has been used as an index of neurovascular coupling. Hippocampal BOLD-CBF correlation is associated with neurocognition, and the reduced correlation is associated with neuropsychiatric disorders. We conducted the first genome-wide association study of the hippocampal BOLD-CBF correlation in 4,832 Chinese Han subjects. The hippocampal BOLD-CBF correlation had an estimated heritability of 16.2-23.9% and showed reliable genome-wide significant association with a locus at 3q28, in which many variants have been linked to neuroimaging and cerebrospinal fluid markers of Alzheimer's disease. Gene-based association analyses showed four significant genes (GMNC, CRTC2, DENND4B, and GATAD2B) and revealed enrichment for mast cell calcium mobilization, microglial cell proliferation, and ubiquitin-related proteolysis pathways that regulate different cellular components of the neurovascular unit. This is the first unbiased identification of the association of hippocampal BOLD-CBF correlation, providing fresh insights into the genetic architecture of hippocampal neurovascular coupling. |
| 2023-10-20 | |
| 语种 | 英语 |
| DOI | 10.1016/j.isci.2023.108005 |
| 发表期刊 | ISCIENCE
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| 卷号 | 26期号:10页码:16 |
| 期刊论文类型 | 实证研究 |
| 收录类别 | SCI |
| 资助项目 | National Key Research and Development Program of China[2018YFC1314300] ; National Natural Science Foundation of China[82030053] ; National Natural Science Foundation of China[81425013] |
| 出版者 | CELL PRESS |
| WOS关键词 | ACCESSORY PROTEIN P56 ; BRAIN ; DISEASE ; SYSTEM ; FMRI ; NEUROGENESIS ; VARIANTS ; MEMORY ; BOLD |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001087019800001 |
| WOS分区 | Q1 |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/46345 |
| 专题 | 认知与发展心理学研究室 |
| 通讯作者 | Yu, Yongqiang; Xian, Junfang; Yu, Chunshui |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China 3.Zhejiang Univ, Affiliated Hosp 2, Dept Radiol, Sch Med, Hangzhou 310009, Peoples R China 4.Wenzhou Med Univ, Affiliated Hosp 2, Dept Radiol, Wenzhou 325027, Peoples R China 5.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China 6.Zhengzhou Univ, Dept Magnet Resonance Imaging, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China 7.Nanjing Univ, Affiliated Hosp, Dept Radiol, Med Sch,Jinling Hosp, Nanjing 210002, Peoples R China 8.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R China 9.Air Force Med Univ, Funct & Mol Imaging Key Lab Shaanxi Prov, Tangdu Hosp, Xian 710038, Peoples R China 10.Air Force Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Peoples R China 11.Chinese Peoples Armed Police Force, Characterist Med Ctr, Dept Radiol, Tianjin 300162, Peoples R China 12.Guangzhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Med Imaging, Guangzhou 510405, Peoples R China 13.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China 14.Tianjin Med Univ, Sch Med Imaging, Tianjin 300203, Peoples R China 15.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Tianjin 300203, Peoples R China 16.Tianjin Med Univ Canc Inst & Hosp, Dept Radiol, Tianjin 300060, Peoples R China 17.Tianjin First Ctr Hosp, Dept Radiol, Tianjin 300192, Peoples R China 18.Univ Sci & Technol China, Div Life Sci & Med, Hefei 230027, Peoples R China 19.Xuzhou Med Univ, Affiliated Hosp, Dept Radiol, Xuzhou 221006, Peoples R China 20.Beijing Normal Univ, McGovern Inst Brain Res, Dev Populat Neurosci Res Ctr IDG, Beijing 100875, Peoples R China 21.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 22.Tianjin Med Univ, Key Lab Canc Prevent & Therapy, Tianjins Clin Res Ctr Canc,Minist Educ, Dept Radiol,Natl Clin Res Ctr Canc,Tianjin Med Un, Tianjin 300060, Peoples R China 23.Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei 230022, Peoples R China 24.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China 25.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Hui,Xu, Xiaojun,Yan, Zhihan,et al. Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population[J]. ISCIENCE,2023,26(10):16. |
| APA | Xue, Hui.,Xu, Xiaojun.,Yan, Zhihan.,Cheng, Jingliang.,Zhang, Longjiang.,...&Yu, Chunshui.(2023).Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population.ISCIENCE,26(10),16. |
| MLA | Xue, Hui,et al."Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population".ISCIENCE 26.10(2023):16. |
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