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Association of P50 with social function, but not with cognition in patients with first-episode schizophrenia | |
Wang, Dongmei1,2; Xia, Luyao1,2; Zhang, Zhiqi3; Guo, Junru1,4; Tian, Yang1,2; Zhou, Huixia1,2; Xiu, Meihong5; Chen, Dachun5; Zhang, Xiang-Yang1,2 | |
第一作者 | Dongmei Wang |
通讯作者邮箱 | zhangxy@psych.ac.cn (xiang-yang zhang) |
心理所单位排序 | 1 |
摘要 | Functional deficits including cognitive impairment and social dysfunction are the core symptoms of schizophrenia (SCZ), and sensory gating (SG) deficits may be involved in the pathological mechanism of functional deficits in SCZ. This study was to investigate the relationship between defective P50 inhibition and functional deficits in first-episode drug na & iuml;ve (FEDN) SCZ patients. A total of 95 FEDN SCZ patients and 53 healthy controls (HC) were recruited. The Chinese version of UCSD Performance-Based Skills (UPSA), MATRICS Consensus Cognitive Battery (MCCB), and EEG system were used to assess the social function, cognitive performance, and P50 inhibition, respectively. The MCCB total score and eight domain scores were significantly lower in patients with FEDN SCZ than those in HC (all p < 0.05). The UPSA total score and financial skills scores were also significantly lower in SCZ patients than that in the HC (all p < 0.05). Compared with HC, patients with FEDF SCZ had a higher P50 ratio (all p < 0.05). There was no correlation between P50 components and MCCB scores in patients with FEDF SCZ. However, there was only a correlation between the P50 ratio and UPSA financial skills, communication skills, or total score in patients (all p < 0.05). Defective P50 inhibition in FEDN SCZ patients may be associated with social dysfunction but not cognitive impairment, suggesting that the social dysfunction and cognitive impairment of patients with FEDN SCZ may have different pathogenic mechanisms. |
关键词 | Schizophrenia P50 Sensory gating Social function Cognition |
2023-11-15 | |
语种 | 英语 |
DOI | 10.1007/s00406-023-01711-w |
发表期刊 | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE |
ISSN | 0940-1334 |
页码 | 10 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | CAS International Cooperation Research Program[153111KYSB20190004] ; Institute of Psychology, CAS[GJ202006] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
出版者 | SPRINGER HEIDELBERG |
WOS关键词 | NEUROCOGNITIVE DEFICITS ; SUPPRESSION DEFICITS ; BIPOLAR DISORDER ; GATING DEFICITS ; DRUG-NAIVE ; BATTERY ; MIND ; IMPAIRMENTS ; PERFORMANCE ; ABILITY |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:001104851100001 |
资助机构 | CAS International Cooperation Research Program ; Institute of Psychology, CAS ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46487 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiang-Yang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Columbia Univ Barnard Coll, Dept Psychol, New York, NY 10027 USA 4.Guizhou Minzu Univ, Dept Psychol, Guiyang 550025, Guizhou, Peoples R China 5.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wang, Dongmei,Xia, Luyao,Zhang, Zhiqi,et al. Association of P50 with social function, but not with cognition in patients with first-episode schizophrenia[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2023:10. |
APA | Wang, Dongmei.,Xia, Luyao.,Zhang, Zhiqi.,Guo, Junru.,Tian, Yang.,...&Zhang, Xiang-Yang.(2023).Association of P50 with social function, but not with cognition in patients with first-episode schizophrenia.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,10. |
MLA | Wang, Dongmei,et al."Association of P50 with social function, but not with cognition in patients with first-episode schizophrenia".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023):10. |
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