Institutional Repository of Key Laboratory of Mental Health, CAS
Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study | |
Peng, Pu1,2; Wang, Dongmei3,4; Wang, Qianjin1,2; Zhou, Yanan5; Hao, Yuzhu1,2; Chen, Shubao1,2; Wu, Qiuxia1,2; Liu, Tieqiao1,2; Zhang, Xiangyang3,4 | |
第一作者 | Pu Peng |
通讯作者邮箱 | liutieqiao123@csu.edu.cn (tieqiao liu) ; zhangxy@psych.ac.cn (xiangyang zhang) |
心理所单位排序 | 3 |
摘要 | Emerging studies indicate that oxidative stress may contribute to deficit syndrome (DS) in patients with schizophrenia. Homocysteine (Hcy) is a well-known marker and mediator of oxidative stress that exhibits tight associations with schizophrenia. However, no previous studies have assessed the relationship of DS with Hcy. This study evaluated the prevalence, clinical characteristics, and association of DS with Hcy in 491 patients with schizophrenia. Plasma levels of Hcy and other metabolic parameters were measured. Positive and Negative Syndrome Scale and the proxy scale for deficit syndrome were employed to assess psychiatric symptoms and DS. The logistic regression model was conducted to assess independent factors associated with DS, and the Area Under the Curve (AUC) was used to assess the performance of our model. There was a high incidence of hyperhomocysteinemia (58.8%) and DS (24.4%). Plasma Hcy levels were significantly higher in patients with DS. Age, Hcy levels, and psychiatric symptoms were independently associated with DS. The combination of these variables perfectly differentiated DS and non-DS patients with an AUC value of 0.89. Our study suggests that elevated Hcy levels may be related to DS. Routine monitoring of Hcy is essential and may facilitate early detection of DS in patients with schizophrenia. |
关键词 | Deficit syndrome Schizophrenia Oxidative stress Homocysteine |
2023-11-09 | |
语种 | 英语 |
DOI | 10.1007/s00406-023-01706-7 |
发表期刊 | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE |
ISSN | 0940-1334 |
页码 | 9 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | We would like to acknowledge all the participants. |
出版者 | SPRINGER HEIDELBERG |
WOS关键词 | OXIDATIVE STRESS ; SERUM-LEVELS ; PREVALENCE ; LEVEL ; BDNF |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:001099149000001 |
WOS分区 | Q1 |
资助机构 | We would like to acknowledge all the participants. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46499 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Liu, Tieqiao; Zhang, Xiangyang |
作者单位 | 1.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha 410011, Hunan, Peoples R China 2.Cent South Univ, Xiangya Hosp 2, Natl Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Hunan Brain Hosp, Hunan Peoples Hosp 2, Dept Psychiat, Changsha, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Peng, Pu,Wang, Dongmei,Wang, Qianjin,et al. Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2023:9. |
APA | Peng, Pu.,Wang, Dongmei.,Wang, Qianjin.,Zhou, Yanan.,Hao, Yuzhu.,...&Zhang, Xiangyang.(2023).Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,9. |
MLA | Peng, Pu,et al."Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023):9. |
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