Institutional Repository of Key Laboratory of Mental Health, CAS
Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain | |
Wenhui Zhao1,2; Lei Zhao1,2; Xianyu Chang1,2; Xuejing Lu1,2; Yiheng Tu1,2 | |
通讯作者邮箱 | yihengtu@gmail.com (yiheng tu) |
心理所单位排序 | 1 |
摘要 | Numerous studies have investigated the impacts of common types of chronic pain (CP) on patients' cognitive function and observed that CP was associated with later dementia. More recently, there is a growing recognition that CP conditions frequently coexist at multiple body sites and may bring more burdens on patients' overall health. However, whether and how multisite CP (MCP) contributes to an increased risk of dementia, compared to single-site CP (SCP) and pain-free (PF), is largely unclear. In the current study, utilizing the UK Biobank cohort, we first investigated dementia risk in individuals (n = 354,943) with different numbers of coexisting CP sites using Cox proportional hazards regression models. We then applied generalized additive models to investigate whether MCP leads to excessive deterioration of participants' (n = 19,116) cognition and brain structure. We found that individuals with MCP were associated with significantly higher dementia risk, broader and faster cognitive impairment, and greater hippocampal atrophy than both PF individuals and those with SCP. Moreover, the detrimental effects of MCP on dementia risk and hippocampal volume aggravated along with the number of coexisting CP sites. Mediation analyses further revealed that the decline of fluid intelligence in MCP individuals was partially mediated by hippocampal atrophy. Our results suggested that cognitive decline and hippocampal atrophy interact biologically and may underlie the increased risk of dementia associated with MCP. |
2023 | |
语种 | 英语 |
DOI | 10.1073/pnas.2215192120 |
发表期刊 | PNAS |
ISSN | 0027-8424 |
卷号 | 120期号:9页码:9 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
Q分类 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46540 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wenhui Zhao,Lei Zhao,Xianyu Chang,et al. Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain[J]. PNAS,2023,120(9):9. |
APA | Wenhui Zhao,Lei Zhao,Xianyu Chang,Xuejing Lu,&Yiheng Tu.(2023).Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain.PNAS,120(9),9. |
MLA | Wenhui Zhao,et al."Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain".PNAS 120.9(2023):9. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Elevated dementia ri(606KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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