The analgesic effects and neural oscillatory mechanisms of virtual reality scenes based on distraction and mindfulness strategies in human volunteers

doi:10.1016/j.bja.2023.09.001

	The analgesic effects and neural oscillatory mechanisms of virtual reality scenes based on distraction and mindfulness strategies in human volunteers
	Li, Jingwei 1,2; Yang, Haoyu1,2 ; Xiao, Yian 1; Liu, Xu 3; Ma, Bingjie 4; Ma, Ke 4; Hu, Li1,2 ; Lu, Xuejing1,2
通讯作者	Ma, Ke(marke72@163.com) ; Lu, Xuejing(luxj@psych.ac.cn)
摘要	Background: Virtual reality (VR) has been widely used as a non-pharmacological adjunct to pain management. However, there is no consensus on what type of VR content is the best for pain alleviation and by what means VR modulates pain perception. We used three experiments to explore the analgesic effect of VR scenes in healthy adult volunteers.Methods: We first compared the effect of immersive VR on pain perception with active (i.e. non-immersive, two-dimensional video) and passive (i.e. no VR or audiovisual input) controls at both subjective perceptual (Experiment 1) and electrophysiological (electroencephalography) levels (Experiment 2), and then explored possible analgesic mechanisms responsible for VR scenes conveying different strategies (e.g. exploration or mindfulness; Experiment 3).Results: The multisensory experience of the VR environment lowered pain intensity and unpleasantness induced by contact heat stimuli when compared with two control conditions (P=0.001 and P<0.001, respectively). The reduced pain intensity rating correlated with decreased P2 amplitude (r=0.433, P<0.001) and increased pre-stimulus spontaneous gamma oscillations (r=-0.339, P=0.004) by 32-channel electroencephalography. A VR exploration scene induced a strong sense of immersion that was associated with increased pre-stimulus gamma oscillations (r=0.529, P<0.001), whereas a VR mindfulness meditation scene had a minor effect on immersive feelings but induced strong pre-stimulus alpha os-cillations (r=-0.550, P<0.001), which led to a comparable analgesic effect.Conclusions: Distinct neural mechanisms are responsible for VR-induced analgesia, deepening our understanding of the analgesic benefits of VR and its neural electrophysiological correlates. These findings support further development of digital healthcare.
关键词	analgesia digital healthcare electroencephalography mindfulness pain virtual reality
	2023-12-01
语种	英语
DOI	10.1016/j.bja.2023.09.001
发表期刊	BRITISH JOURNAL OF ANAESTHESIA
ISSN	0007-0912
卷号	131 期号:6 页码:1082-1092
收录类别	SCI
资助项目	National Natural Science Foundation of China[32171077] ; National Natural Science Foundation of China[32071061] ; Youth Innovation Promotion Association, CAS ; Beijing Natural Science Foundation[JQ22018] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4015]
出版者	ELSEVIER SCI LTD
WOS关键词	PAIN-CONTROL ; SYSTEM
WOS研究方向	Anesthesiology
WOS类目	Anesthesiology
WOS记录号	WOS:001112326000001
资助机构	National Natural Science Foundation of China ; Youth Innovation Promotion Association, CAS ; Beijing Natural Science Foundation ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/46580
专题	中国科学院心理健康重点实验室
通讯作者	Ma, Ke; Lu, Xuejing
作者单位	1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Liaoning Normal Univ, Res Ctr Brain & Cognit Neurosci, Dalian, Peoples R China 4.Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Pain Management, Sch Med, Shanghai, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Jingwei,Yang, Haoyu,Xiao, Yian,et al. The analgesic effects and neural oscillatory mechanisms of virtual reality scenes based on distraction and mindfulness strategies in human volunteers[J]. BRITISH JOURNAL OF ANAESTHESIA,2023,131(6):1082-1092.
APA	Li, Jingwei.,Yang, Haoyu.,Xiao, Yian.,Liu, Xu.,Ma, Bingjie.,...&Lu, Xuejing.(2023).The analgesic effects and neural oscillatory mechanisms of virtual reality scenes based on distraction and mindfulness strategies in human volunteers.BRITISH JOURNAL OF ANAESTHESIA,131(6),1082-1092.
MLA	Li, Jingwei,et al."The analgesic effects and neural oscillatory mechanisms of virtual reality scenes based on distraction and mindfulness strategies in human volunteers".BRITISH JOURNAL OF ANAESTHESIA 131.6(2023):1082-1092.