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Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods | |
Yang, Jin1; Huggins, Ashley A.2,3; Sun, Delin2,3,4; Baird, C. Lexi2,3; Haswell, Courtney C.2,3; Frijling, Jessie L.5; Olff, Miranda5,6; van Zuiden, Mirjam5; Koch, Saskia B. J.5,7; Nawijn, Laura5; Veltman, Dick J.5; Suarez-Jimenez, Benjamin8; Zhu, Xi9,10; Neria, Yuval9,10; Hudson, Anna R.11; Mueller, Sven C.11; Baker, Justin T.12,13; Lebois, Lauren A. M.12,14; Kaufman, Milissa L.12,15; Qi, Rongfeng16; Lu, Guang Ming16; Riha, Pavel17,18,19; Rektor, Ivan19; Dennis, Emily L.20,21; Ching, Christopher R. K.22; Thomopoulos, Sophia I.22; Salminen, Lauren E.22; Jahanshad, Neda22; Thompson, Paul M.22; Stein, Dan J.23,24; Koopowitz, Sheri M.23,24; Ipser, Jonathan C.23,24; Seedat, Soraya25; du Plessis, Stefan25; van den Heuvel, Leigh L.25; Wang, Li26,27; Zhu, Ye26,27; Li, Gen26,27; Sierk, Anika28; Manthey, Antje28; Walter, Henrik28; Daniels, Judith K.29; Schmahl, Christian30; Herzog, Julia I.30; Liberzon, Israel31; King, Anthony32; Angstadt, Mike32; Davenport, Nicholas D.33,34; Sponheim, Scott R.33,34; Disner, Seth G.33,34; Straube, Thomas35; Hofmann, David35; Grupe, Daniel W.36; Nitschke, Jack B.37; Davidson, Richard J.36,37,38; Larson, Christine L.39; deRoon-Cassini, Terri A.40,41; Blackford, Jennifer U.42,43; Olatunji, Bunmi O.44; Gordon, Evan M.1; May, Geoffrey45,46,47,48; Nelson, Steven M.45,46,47,48; Abdallah, Chadi G.49,50; Levy, Ifat51,52,53,54,55; Harpaz-Rotem, Ilan49,53,55; Krystal, John H.49,55; Morey, Rajendra A.2,3; Sotiras, Aristeidis1,56 | |
第一作者 | Jin Yang |
通讯作者邮箱 | rajendra.morey@duke.edu |
摘要 | Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions. |
2023-11-28 | |
语种 | 英语 |
DOI | 10.1038/s41386-023-01763-5 |
发表期刊 | NEUROPSYCHOPHARMACOLOGY |
ISSN | 0893-133X |
页码 | 11 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | U.S. Department of Health & Human Services | National Institutes of Health (NIH) |
出版者 | SPRINGERNATURE |
WOS关键词 | DORSOLATERAL PREFRONTAL CORTEX ; MAJOR DEPRESSIVE DISORDER ; HIPPOCAMPAL VOLUME ; THICKNESS ; PTSD ; CINGULATE ; VETERANS ; TRAUMA ; CHILDHOOD ; HARMONIZATION |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
WOS类目 | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
WOS记录号 | WOS:001123265200001 |
WOS分区 | Q1 |
资助机构 | U.S. Department of Health & Human Services | National Institutes of Health (NIH) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46739 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Morey, Rajendra A. |
作者单位 | 1.Washington Univ, Dept Radiol, St Louis, MO 63110 USA 2.Duke Univ, Duke UNC Brain Imaging & Anal Ctr, Durham, NC 27708 USA 3.Durham VA Med Ctr, Mid Atlantic Mental Illness Res Educ & Clin Ctr, Durham, NC USA 4.Educ Univ Hong Kong, Dept Psychol, Hong Kong, Peoples R China 5.Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands 6.ARQ Natl Psychotrauma Ctr, Diemen, Netherlands 7.Radboud Univ Nijmegen, Ctr Cognit Neuroimaging, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands 8.Univ Rochester, Med Ctr, Del Monte Inst Neurosci, Rochester, NY 14642 USA 9.Columbia Univ, Med Ctr, Dept Psychiat, New York, NY USA 10.New York State Psychiat Inst & Hosp, New York, NY USA 11.Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium 12.Harvard Med Sch, Dept Psychiat, Boston, MA USA 13.Harvard Univ, McLean Hosp, Inst Technol Psychiat, Belmont, MA 02178 USA 14.McLean Hosp, Div Depress & Anxiety Disorders, Belmont, MA 02478 USA 15.McLean Hosp, Div Womens Mental Hlth, Belmont, MA USA 16.Nanjing Univ, Jinling Hosp, Dept Med Imaging, Med Sch, Nanjing, Jiangsu, Peoples R China 17.Masaryk Univ, St Annes Hosp, Dept Neurol 1, Brno, Czech Republic 18.Masaryk Univ, Fac Med, Brno, Czech Republic 19.Masaryk Univ, CEITEC Cent European Inst Technol, Multimodal & Funct Neuroimaging Res Grp, Brno, Czech Republic 20.Univ Utah, Dept Neurol, Salt Lake City, UT USA 21.George E Wahlen Vet Affairs Med Ctr, Salt Lake City, UT USA 22.USC, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA 23.Univ Cape Town, Dept Psychiat, Cape Town, South Africa 24.Univ Cape Town, Neurosci Inst, Cape Town, South Africa 25.Stellenbosch Univ, Dept Psychiat, Cape Town, South Africa 26.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China 27.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 28.Charite, Univ Med Ctr, Berlin, Germany 29.Univ Groningen, Dept Clin Psychol, Groningen, Netherlands 30.Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Psychosomat Med & Psychotherapy, Heidelberg, Germany 31.Texas A&M Univ, Dept Psychiat & Behav Sci, College Stn, TX 77843 USA 32.Univ Michigan, Dept Psychiat, Ann Arbor, MI USA 33.Minneapolis VA Hlth Care Syst, Minneapolis, MN USA 34.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA 35.Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany 36.Univ Wisconsin Madison, Ctr Hlth Minds, Madison, WI USA 37.Univ Wisconsin, Dept Psychiat, Madison, WI USA 38.Univ Wisconsin, Dept Psychol, Madison, WI USA 39.Univ Wisconsin, Dept Psychol, Milwaukee, WI USA 40.Med Coll Wisconsin, Dept Surg, Div Trauma & Acute Care Surg, Milwaukee, WI USA 41.Med Coll Wisconsin, Comprehens Injury Ctr, Milwaukee, WI USA 42.Univ Nebraska Med Ctr, Munroe Meyer Inst, Omaha, NE USA 43.Vanderbilt Univ, Med Ctr, Dept Psychiat & Behav Sci, Nashville, TN USA 44.Vanderbilt Univ, Dept Psychol, Nashville, TN USA 45.Vet Integrated Serv Network 17 Ctr Excellence Res, Waco, TX USA 46.Baylor Univ, Dept Psychol & Neurosci, Waco, TX USA 47.Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Dallas, TX 75235 USA 48.Texas A&M Univ, Hlth Sci Ctr, Dept Psychiat & Behav Sci, Bryan, TX 77843 USA 49.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA 50.Baylor Coll Med, Dept Psychiat Behav Sci, Houston, TX USA 51.Yale Univ, Dept Comparat Med, New Haven, CT 06520 USA 52.Yale Univ, Dept Neurosci, New Haven, CT USA 53.Yale Univ, Dept Psychol, New Haven, CT USA 54.Yale Univ, Wu Tsai Inst, New Haven, CT USA 55.Natl Ctr PTSD, Clin Neurosci Div, West Haven, CT USA 56.Washington Univ, Inst Informat Data Sci & Biostat, St Louis, MO USA |
推荐引用方式 GB/T 7714 | Yang, Jin,Huggins, Ashley A.,Sun, Delin,et al. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods[J]. NEUROPSYCHOPHARMACOLOGY,2023:11. |
APA | Yang, Jin.,Huggins, Ashley A..,Sun, Delin.,Baird, C. Lexi.,Haswell, Courtney C..,...&Sotiras, Aristeidis.(2023).Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods.NEUROPSYCHOPHARMACOLOGY,11. |
MLA | Yang, Jin,et al."Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods".NEUROPSYCHOPHARMACOLOGY (2023):11. |
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