Institutional Repository of Key Laboratory of Mental Health, CAS
The predictive role of early inflammation and oxidative stress and the dynamics of cytokines networks in post-stroke depression | |
Wen, Lulu1; Yan, Chuming1; Si, Tong3; Huang, Liyuan1; Nie, Yuting1; Shen, Huixin1; Qu, Miao1; Zhang, Xiangyang2,4 | |
第一作者 | Lulu Wen |
通讯作者邮箱 | qumiao@xwhosp.org (m. qu) ; zhangay@psych.ac.cn (x. zhang) |
心理所单位排序 | 2 |
摘要 | Backgrounds: Chronic inflammation and oxidative stress play an important role in the pathogenesis of PSD. The main purposes of this study were to examine the dynamic changes of cytokines networks in PSD and the predictive role of early inflammation and oxidative stress for 2-week PSD.Methods: Patients with ischemic stroke were recruited on day 3, and those with Hamilton Depression Rating Scale 24-Item (HAMD-24) >= 8 were classified as ischemic stroke patients with depressive symptoms and others as ischemic stroke patients without depressive symptoms. Subjects were then followed up at 2 weeks and 3 months, with those meeting diagnostic criteria for depressive symptoms on the HAMD >= 8 and the Statistical Manual of Mental Disorders-V (DSM-V) as the PSD group, and the others as the non-PSD group.Results: At 3 days, IFN-gamma, IL-12(p70), IL-12(p40), IL-2, IL-28A/IFN lambda 2, and IL-19 were elevated in ischemic stroke patients with depressive symptoms. At 2 weeks, IL-12(p40), IL-19, IL-22, IFN-beta and MMP-1 all were increased in PSD patients. At 3 months, IL-2, IFN-beta and sCD163 increased in PSD group. Longitudinally, the inflammatory response decreased significantly in PSD group from 2 weeks to 3 months of follow-up, while it gradually decreased in non-PSD group from 3 days to 3 months of follow-up. SOD was positively related to IL-12(p70), IFN-gamma and IL-20. Plasma IFN-gamma at 3 days may be a potential predictive biomarker for 2-week PSD.Conclusions: Peripheral inflammation and oxidative stress are involved in the pathogenesis of PSD, providing new insights for its diagnosis and treatment. |
关键词 | Post stroke depression Cytokines Oxidative stress Biomarker Inflammation |
2024-02-15 | |
语种 | 英语 |
DOI | 10.1016/j.jad.2023.12.012 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 347页码:469-476 |
期刊论文类型 | 实证研究 |
收录类别 | SCI ; SSCI |
资助项目 | National Natural Science Founda-tion of China[81973759] ; National Natural Science Founda-tion of China[82274444] |
出版者 | ELSEVIER |
WOS关键词 | BRAIN INFLAMMATION ; SERUM-LEVELS ; RAT MODEL ; STROKE ; ASSOCIATION ; TH1 ; SYMPTOMS |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:001134020800001 |
WOS分区 | Q1 |
资助机构 | National Natural Science Founda-tion of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46754 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Qu, Miao; Zhang, Xiangyang |
作者单位 | 1.Capital Med Univ, Neurol Dept, Xuan Wu Hosp, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Beijing Shijitan Hosp, Neurol Dept, Beijing, Peoples R China 4.16 Lincui Rd, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wen, Lulu,Yan, Chuming,Si, Tong,et al. The predictive role of early inflammation and oxidative stress and the dynamics of cytokines networks in post-stroke depression[J]. JOURNAL OF AFFECTIVE DISORDERS,2024,347:469-476. |
APA | Wen, Lulu.,Yan, Chuming.,Si, Tong.,Huang, Liyuan.,Nie, Yuting.,...&Zhang, Xiangyang.(2024).The predictive role of early inflammation and oxidative stress and the dynamics of cytokines networks in post-stroke depression.JOURNAL OF AFFECTIVE DISORDERS,347,469-476. |
MLA | Wen, Lulu,et al."The predictive role of early inflammation and oxidative stress and the dynamics of cytokines networks in post-stroke depression".JOURNAL OF AFFECTIVE DISORDERS 347(2024):469-476. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
The predictive role (3816KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论