Institutional Repository of Key Laboratory of Mental Health, CAS
Dynamic Changes of the Infralimbic Cortex and Its Regulation of the Prelimbic Cortex in Rats with Chronic Inflammatory Pain | |
Ma, Longyu1; Yue, Lupeng2,3; Liu, Shuting1; Zhang, Yu1,4; Zhang, Meng1,5; Cui, Shuang1; Liu, Feng-Yu1; Yi, Ming1,6; Wan, You1,6,7 | |
第一作者 | Longyu Ma |
通讯作者邮箱 | mingyi@hsc.pku.edu.cn (ming yi) ; ywan@hsc.pku.edu.cn (yu wan) |
心理所单位排序 | 1 |
摘要 | The prelimbic cortex (PL) is actively engaged in pain modulation. The infralimbic cortex (IL) has been reported to regulate the PL. However, how this regulation affects pain remains unclear. In the present study, we recorded temporary hyper-activity of PL pyramidal neurons responding to nociceptive stimuli, but a temporary hypo-function of the IL by in vivo electrophysiological recording in rats with peripheral inflammation. Manipulation of the PL or IL had opposite effects on thermal hyperalgesia. Furthermore, the functional connectivity and chemogenetic regulation between the subregions indicated an inhibitory influence of the IL on the PL. Activation of the pathway from the IL to the PL alleviated thermal hyperalgesia, whereas its inhibition exacerbated chronic pain. Overall, our results suggest a new mechanism underlying the role of the medial prefrontal cortex in chronic pain: hypo-function of the IL leads to hyperactivity of the PL, which regulates thermal hyperalgesia, and thus contributes to the chronicity of pain. |
关键词 | Prefrontal cortex Prelimbic cortex Infralimbic cortex Inhibitory regulation Chronic pain |
2024-01-05 | |
语种 | 英语 |
DOI | 10.1007/s12264-023-01159-x |
发表期刊 | NEUROSCIENCE BULLETIN |
ISSN | 1673-7067 |
页码 | 15 |
期刊论文类型 | 综述 |
收录类别 | SCI |
资助项目 | National Natural Foundation of China[32371049] ; National Natural Foundation of China[32271053] ; National Natural Foundation of China[31872774] ; National Natural Foundation of China[81974166] ; National Natural Foundation of China[81821092] ; National Natural Foundation of China[82101303] ; National Natural Foundation of China[32000749] ; Beijing Natural Science Foundation[L222016] ; China Postdoctoral Science Foundation[2020M670061] ; Tianjin Key Laboratory of Brain Science and Neuroengineering ; Postdoctoral Fellowship of the Peking-Tsinghua Center for Life Sciences |
出版者 | SPRINGER |
WOS关键词 | MEDIAL PREFRONTAL CORTEX ; FEAR EXTINCTION ; FUNCTIONAL CONNECTIVITY ; MEMORY RECONSOLIDATION ; INTERCALATED NEURONS ; PROJECTIONS ; NOCICEPTION ; RETRIEVAL ; BRAIN ; CELLS |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:001136763200001 |
WOS分区 | Q1 |
资助机构 | National Natural Foundation of China ; Beijing Natural Science Foundation ; China Postdoctoral Science Foundation ; Tianjin Key Laboratory of Brain Science and Neuroengineering ; Postdoctoral Fellowship of the Peking-Tsinghua Center for Life Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46799 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Yi, Ming; Wan, You |
作者单位 | 1.Peking Univ, Neurosci Res Inst, Dept Neurobiol, Sch Basic Med Sci, Beijing 100083, Peoples R China 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China 4.CAMS & PUMC, Inst Lab Anim Sci, NHC Key Lab Human Dis Comparat Med, Beijing 100021, Peoples R China 5.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Pathol, Beijing 100045, Peoples R China 6.Peking Univ, Key Lab Neurosci, Minist Educ, Natl Hlth Commiss, Beijing 100083, Peoples R China 7.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China |
推荐引用方式 GB/T 7714 | Ma, Longyu,Yue, Lupeng,Liu, Shuting,et al. Dynamic Changes of the Infralimbic Cortex and Its Regulation of the Prelimbic Cortex in Rats with Chronic Inflammatory Pain[J]. NEUROSCIENCE BULLETIN,2024:15. |
APA | Ma, Longyu.,Yue, Lupeng.,Liu, Shuting.,Zhang, Yu.,Zhang, Meng.,...&Wan, You.(2024).Dynamic Changes of the Infralimbic Cortex and Its Regulation of the Prelimbic Cortex in Rats with Chronic Inflammatory Pain.NEUROSCIENCE BULLETIN,15. |
MLA | Ma, Longyu,et al."Dynamic Changes of the Infralimbic Cortex and Its Regulation of the Prelimbic Cortex in Rats with Chronic Inflammatory Pain".NEUROSCIENCE BULLETIN (2024):15. |
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