Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naive major depressive disorder

doi:10.1038/s41598-023-43166-y

	Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naive major depressive disorder
	Liu, Junjun 1,2,3; Li, Zhe 2; Jia, Fengnan 2,3; Yuan, Hsinsung 1; Zhou, Yue 2,4; Xia, Xingzhi 2,4; Yang, Ruchang 2,3; Wu, Yuxuan 2,3; Zhang, Xiaobin 2; Ye, Gang 2; Du, Xiangdong 2,3; Zhang, Xiangyang5
通讯作者	Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
摘要	Controversial evidence exists on the relationship between body mass index (BMI) and suicide attempts (SA) in patients with major depressive disorder (MDD). This cross-sectional study aimed to explore the association between BMI and SA in first-episode drug-naive (FEDN) MDD patients in China. The study was conducted from 2016 to 2018 in Taiyuan, China. Univariate and multivariate logistic regression analyzed the BMI-SA association, with subgroup analysis for gender. Threshold effects were examined using two-piecewise regression. In males, BMI was significantly associated with SA (OR=0.84, 95% CI 0.74-0.94, P=0.003) after full adjustment, but not in females (OR=0.97, 95% CI 0.89-1.06, P=0.541). The interaction with gender was significant (P for interaction<0.05). Smoothing plots revealed an L-shaped BMI-SA relationship in both genders, with BMI inflection points at 27.3 kg/m(2) in males and 21.4 kg/m(2) in females. Below the inflection points, BMI is negatively associated with SA in males (OR=0.75, 95% CI 0.66-0.86, P<0.001) and females (OR=0.48, 95% CI 0.32-0.72, P<0.001). Above the inflection points, no association existed for both genders (all P>0.05). Results showed an L-shaped nonlinear BMI-SA relationship in FEDN MDD patients but differing BMI inflection points between genders, thus contributing to effective prevention programs for suicide.
	2023-09-25
语种	英语
DOI	10.1038/s41598-023-43166-y
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	13 期号:1 页码:12
收录类别	SCI
资助项目	Suzhou Gusu Health Talents Scientific Research Project[GSWS2021053] ; Suzhou Gusu Health Talents Scientific Research Project[GSWS2019070] ; Key Diagnosis and treatment Program of Suzhou[LCZX202016] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK21216] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK20184] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK22264] ; Suzhou clinical Medical Center for mood disorders[Szlcyxzx202109]
出版者	NATURE PORTFOLIO
WOS关键词	SEX-DIFFERENCES ; OBESITY ; RISK ; POPULATION ; PREVALENCE ; CITALOPRAM ; BEHAVIORS ; SEVERITY ; IDEATION ; EFFICACY
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001116558400071
资助机构	Suzhou Gusu Health Talents Scientific Research Project ; Key Diagnosis and treatment Program of Suzhou ; Medical Science and Technology Development Foundation, Nanjing Department of Health ; Suzhou clinical Medical Center for mood disorders
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/46823
专题	中国科学院心理健康重点实验室
通讯作者	Du, Xiangdong; Zhang, Xiangyang
作者单位	1.Nanjing Meishan Hosp, Nanjing 210041, Peoples R China 2.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Dept Psychiat, Suzhou 215137, Peoples R China 3.Soochow Univ, Med Coll, Suzhou 215137, Peoples R China 4.Xuzhou Med Univ, Xuzhou 221004, Jiangsu, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Junjun,Li, Zhe,Jia, Fengnan,et al. Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naive major depressive disorder[J]. SCIENTIFIC REPORTS,2023,13(1):12.
APA	Liu, Junjun.,Li, Zhe.,Jia, Fengnan.,Yuan, Hsinsung.,Zhou, Yue.,...&Zhang, Xiangyang.(2023).Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naive major depressive disorder.SCIENTIFIC REPORTS,13(1),12.
MLA	Liu, Junjun,et al."Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naive major depressive disorder".SCIENTIFIC REPORTS 13.1(2023):12.