Institutional Repository of Key Laboratory of Mental Health, CAS
Prevalence and risk factors for subclinical hypothyroidism in older patients with major depressive disorder | |
Li, Min1; Wang, Xiu-Wen1; Wang, Xiao-Qian2; Zhang, Jian-Jun2,3,4; Zhang, Xiang-Yang4,5 | |
第一作者 | Min Li |
通讯作者邮箱 | qxzhangjianjun@126.com (jian-jun zhang) ; zhanqxy@psych.ac.cn (xiang-yang zhang) |
心理所单位排序 | 4 |
摘要 | Background Subclinical hypothyroidism (SCH) is highly correlated with major depressive disorder (MDD). However, the prevalence and risk factors for SCH in older patients with MDD have rarely been reported in China. Methods This cross-sectional study included 266 older MDD patients with SCH was performed. Clinical and anthropometric, biochemical, and thyroid function data were collected. Depression, anxiety, and psychotic symptoms were assessed using the Hamilton Depression Scale, the Hamilton Anxiety Scale, and the Positive and Negative Syndrome Scale positive subscale, respectively. Results Among older patients with MDD, the prevalence of SCH was 64.7% (172/266). Compared to patients without SCH, older MDD patients with SCH had a longer disease course and higher TSH, A-TG, A-TPO, HDL-C, LDL-C, TC, FPG, and systolic pressure levels (all P <= 0.002). Furthermore, disease progression (OR 1.082, 95% CI 1.020-1.147, P = 0.009), A-TG (OR 1.005, 95% CI 1.001-1.009, P = 0.017), TC (OR 2.024, 95% CI 1.213-3.377, P = 0.007), FPG (OR 2.916, 95% CI 1.637-5.194, P < 0.001), systolic pressure (OR 1.053, 95% CI 1.008-1.100, P = 0.022) were independently associated with SCH, in older patients with MDD. Conclusions Our findings suggest a high prevalence of SCH in older patients with MDD. Several demographic and clinical variables were independently associated with SCH in older patients with MDD. |
关键词 | Subclinical hypothyroidism (SCH) Major depressive disorder (MDD) Older patients Fasting plasma glucose (FPG) Total cholesterol (TC) |
2024-01-04 | |
语种 | 英语 |
DOI | 10.1186/s12877-023-04584-9 |
发表期刊 | BMC GERIATRICS |
卷号 | 24期号:1页码:8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI ; SSCI |
资助项目 | Natural Science Foundation project of Shanxi Province |
出版者 | BMC |
WOS关键词 | CARDIOVASCULAR RISK ; THYROID-DYSFUNCTION ; GENDER-DIFFERENCES ; POPULATION ; TSH ; REPLICATION ; ASSOCIATION ; SUICIDE ; GLUCOSE |
WOS研究方向 | Geriatrics & Gerontology |
WOS类目 | Geriatrics & Gerontology ; Gerontology |
WOS记录号 | WOS:001136763800006 |
WOS分区 | Q1 |
资助机构 | Natural Science Foundation project of Shanxi Province |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46833 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Jian-Jun; Zhang, Xiang-Yang |
作者单位 | 1.Shanxi Univ Chinese Med, Inst Pharmaceut & Food Engn, Jinzhong, Peoples R China 2.Shanxi Univ Chinese Med, Natl Int Joint Res Ctr Mol Chinese Med, Shanxi Key Lab Chinese Med Encephalopathy, Jinzhong 030619, Shanxi, Peoples R China 3.Shanxi Univ Chinese Med, Expt Management Ctr, Jinzhong, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Li, Min,Wang, Xiu-Wen,Wang, Xiao-Qian,et al. Prevalence and risk factors for subclinical hypothyroidism in older patients with major depressive disorder[J]. BMC GERIATRICS,2024,24(1):8. |
APA | Li, Min,Wang, Xiu-Wen,Wang, Xiao-Qian,Zhang, Jian-Jun,&Zhang, Xiang-Yang.(2024).Prevalence and risk factors for subclinical hypothyroidism in older patients with major depressive disorder.BMC GERIATRICS,24(1),8. |
MLA | Li, Min,et al."Prevalence and risk factors for subclinical hypothyroidism in older patients with major depressive disorder".BMC GERIATRICS 24.1(2024):8. |
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