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Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup | |
Huggins, Ashley A.1,2; Baird, C. Lexi1,2; Briggs, Melvin1,2; Laskowitz, Sarah1,2; Hussain, Ahmed1,2; Fouda, Samar1,2,3; Haswell, Courtney1,2; Sun, Delin1,2,4; Salminen, Lauren E.1,5; Jahanshad, Neda5; Thomopoulos, Sophia I.5; Veltman, Dick J.6; Frijling, Jessie L.7,8; Olff, Miranda7; van Zuiden, Mirjam7,9; Koch, Saskia B. J.7,10; Nawjin, Laura7; Wang, Li11,12; Zhu, Ye11,12; Li, Gen11,13; Stein, Dan J.14,15; Ipser, Jonathan; Seedat, Soraya16,17; du Plessis, Stefan16,17; van den Heuvel, Leigh L.16,17; Suarez-Jimenez, Benjamin18; Zhu, Xi19; Kim, Yoojean20; He, Xiaofu19,20; Zilcha-Mano, Sigal21; Lazarov, Amit19,22; Neria, Yuval19,20; Stevens, Jennifer S.23; Ressler, Kerry J.23,24,25; Jovanovic, Tanja23,26; van Rooij, Sanne J. H.23; Fani, Negar23; Hudson, Anna R.27; Mueller, Sven C.27; Sierk, Anika28; Manthey, Antje28; Walter, Henrik28; Daniels, Judith K.29; Schmahl, Christian30; Herzog, Julia I.30; Riha, Pavel31,32,33; Rektor, Ivan33; Lebois, Lauren A. M.34; Kaufman, Milissa L.25,35; Olson, Elizabeth A.25,34; Baker, Justin T.25,36; Rosso, Isabelle M.25,34; King, Anthony P.37; Liberzon, Isreal38; Angstadt, Mike39; Davenport, Nicholas D.40,41; Sponheim, Scott R.40,41; Disner, Seth G.40,41; Straube, Thomas42; Hofmann, David42; Qi, Rongfeng; Lu, Guang Ming43; Baugh, Lee A.44,45,46; Forster, Gina L.44,45,47; Simons, Raluca M.45,48,49; Simons, Jeffrey S.46,48; Magnotta, Vincent A.50,51,52; Fercho, Kelene A.44,45,46,53; Maron-Katz, Adi54; Etkin, Amit54,55; Cotton, Andrew S.56; O'Leary, Erin N.56; Xie, Hong57; Wang, Xin56; Quide, Yann58,59; El-Hage, Wissam60,61; Lissek, Shmuel62; Berg, Hannah62; Bruce, Steven63; Cisler, Josh64; Ross, Marisa65; Herringa, Ryan J.66; Grupe, Daniel W.67; Nitschke, Jack B.68; Davidson, Richard J.67,68,69; Larson, Christine L.70; deRoon-Cassini, Terri A.71,72; Tomas, Carissa W.72,73; Fitzgerald, Jacklynn M.74; Blackford, Jennifer Urbano75,76; Olatunji, Bunmi O.77; Kremen, William S.78,79; Lyons, Michael J.80; Franz, Carol E.79; Gordon, Evan M.81; May, Geoffrey82,83,84,85; Nelson, Steven M.86,87; Abdallah, Chadi G.88,89; Levy, Ifat90,91,92,93; Harpaz-Rotem, Ilan93,94; Krystal, John H.93; Dennis, Emily L.95,96; Tate, David F.95,96; Cifu, David X.97; Walker, William C.97,98; Wilde, Elizabeth A.95,96,99; Harding, Ian H.100,101; Kerestes, Rebecca100; Thompson, Paul M.5; Morey, Rajendra1,2 | |
第一作者 | Ashley A. Huggins |
摘要 | Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p(-FDR) < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD. |
2024-01-10 | |
语种 | 英语 |
DOI | 10.1038/s41380-023-02352-0 |
发表期刊 | MOLECULAR PSYCHIATRY |
ISSN | 1359-4184 |
页码 | 13 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
出版者 | SPRINGERNATURE |
WOS关键词 | VOXEL-BASED MORPHOMETRY ; EARLY-ONSET SCHIZOPHRENIA ; HIPPOCAMPAL VOLUME ; FUNCTIONAL TOPOGRAPHY ; DISSOCIATIVE SUBTYPE ; BRAIN VOLUMES ; WHITE-MATTER ; GREY-MATTER ; FEAR ; GRAY |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry |
WOS记录号 | WOS:001139041100002 |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46876 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Huggins, Ashley A. |
作者单位 | 1.Duke Univ, Brain Imaging & Anal Ctr, Durham, NC 27706 USA 2.Dept Vet Affairs Mid Atlant Mental Illness Res, Educ & Clin Ctr, Durham, NC 27708 USA 3.Duke Sch Med, Dept Psychiat & Behav Sci, Durham, NC USA 4.Educ Univ Hong Kong, Dept Psychol, Hong Kong, Peoples R China 5.Keck Sch Med USC, Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA 6.Amsterdam UMC Vrije Univ, Amsterdam Neurosci, Psychiat, Amsterdam, Netherlands 7.Amsterdam UMC Univ Amsterdam, Amsterdam Neurosci, Psychiat, Amsterdam, Netherlands 8.Erasmus MC, Dept Psychiat, Rotterdam, Netherlands 9.ARQ Natl Psychotrauma Ctr, Diemen, Netherlands 10.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, Nijmegen, Netherlands 11.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China 12.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 13.NYU Shanghai, Ctr Global Hlth Equ, Shanghai, Peoples R China 14.Univ Cape Town, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa 15.Univ Cape Town, Neurosci Inst, Cape Town, South Africa 16.Univ Stellenbosch, Dept Psychiat, Cape Town, South Africa 17.Stellenbosch Univ, Dept Psychiat, South African Med Res Council Unit, Genom Brain Disorders GBD, Stellenbosch, South Africa 18.Univ Rochester, Med Ctr, Dept Neurosci, Rochester, NY USA 19.Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA 20.New York State Psychiat Inst & Hosp, New York, NY USA 21.Univ Haifa, Haifa, Israel 22.Tel Aviv Univ, Tel Aviv, Israel 23.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA 24.McLean Hosp, Div Depress & Anxiety Disorders, Belmont, MA USA 25.Harvard Med Sch, Dept Psychiat, Boston, MA USA 26.Wayne State Univ, Dept Psychiat & Behav Neurosci, Sch Med, Detroit, MI USA 27.Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium 28.Univ Med Ctr Charite, Berlin, Germany 29.Univ Groningen, Dept Clin Psychol, Groningen, Netherlands 30.Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Psychosomat Med & Psychotherapy, Heidelberg, Germany 31.St Annes Univ Hosp, Dept Neurol 1, Brno, Czech Republic 32.Masaryk Univ, Fac Med, Brno, Czech Republic 33.Masaryk Univ, CEITEC Cent European Inst Technol, Multimodal & Funct Neuroimaging Res Grp, Brno, Czech Republic 34.Harvard Univ, McLean Hosp, Ctr Depress Anxiety & Stress Res, Belmont, MA USA 35.McLean Hosp, Div Womens Mental Hlth, Belmont, MA USA 36.McLean Hosp, Inst Technol Psychiat, Belmont, MA USA 37.Ohio State Univ, Inst Behav Med Res, Dept Psychiat & Behav Hlth, Columbus, OH USA 38.Texas A&M Univ, Dept Psychiat, Bryan, TX USA 39.Univ Michigan, Dept Psychiat, Ann Arbor, MI USA 40.Minneapolis VA Hlth Care Syst, Minneapolis, MN USA 41.Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN USA 42.Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany 43.Nanjing Univ, Jinling Hosp, Med Sch, Dept Med Imaging, Nanjing, Jiangsu, Peoples R China 44.Univ South Dakota, Sanford Sch Med, Div Basic Biomed Sci, Vermillion, SD USA 45.Univ South Dakota, Ctr Brain & Behav Res, Vermillion, SD USA 46.Sioux Falls VA Hlth Care Syst, Sioux Falls, SD USA 47.Univ Otago, Dept Anat, Brain Hlth Res Ctr, Dunedin, New Zealand 48.Univ South Dakota, Dept Psychol, Vermillion, SD USA 49.Disaster Mental Hlth Inst, Vermillion, SD USA 50.Univ Iowa, Dept Radiol, Iowa City, IA USA 51.Univ Iowa, Dept Psychiat, Iowa City, IA USA 52.Univ Iowa, Dept Biomed Engn, Iowa City, IA USA 53.US Fed Aviat Adm, Civil Aerosp Med Inst, Oklahoma City, OK USA 54.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA USA 55.VA Palo Alto Hlth Care Syst, Palo Alto, CA USA 56.Univ Toledo, Dept Psychiat, Toledo, OH USA 57.Univ Toledo, Dept Neurosci, Toledo, OH USA 58.Univ New South Wales UNSW Sydney, Sch Psychol, Sydney, NSW, Australia 59.Neurosci Res Australia, Randwick, NSW, Australia 60.Univ Tours, UMR1253, INSERM, Tours, France 61.CHRU Tours, CIC1415, INSERM, Tours, France 62.Univ Minnesota, Dept Psychol, Minneapolis, MN USA 63.Univ Missouri St Louis, Ctr Trauma Recovery, Dept Psychol Sci, St Louis, MO USA 64.Univ Texas Austin, Dept Psychiat, Austin, TX USA 65.Northwestern Univ, Northwestern Neighborhood & Network Initiat, Inst Policy Res, Evanston, IL USA 66.Univ Wisconsin Madison, Sch Med & Publ Hlth, Madison, WI USA 67.Univ Wisconsin Madison, Ctr Healthy Minds, Madison, WI USA 68.Univ Wisconsin Madison, Dept Psychiat, Madison, WI USA 69.Univ Wisconsin Madison, Dept Psychol, Madison, WI USA 70.Univ Wisconsin Milwaukee, Dept Psychol, Milwaukee, WI USA 71.Med Coll Wisconsin, Dept Surg, Div Trauma & Acute Care Surg, Milwaukee, WI USA 72.Med Coll Wisconsin, Comprehens Injury Ctr, Milwaukee, WI USA 73.Med Coll Wisconsin Milwaukee, Inst Hlth & Equity, Div Epidemiol & Social Sci, Milwaukee, WI USA 74.Marquette Univ, Dept Psychol, Milwaukee, WI USA 75.Univ Nebraska Med Ctr, Munroe Meyer Inst, Omaha, NE USA 76.Vanderbilt Univ, Dept Psychiat & Behav Sci, Med Ctr, Nashville, TN USA 77.Vanderbilt Univ, Dept Psychol, Nashville, TN USA 78.Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA 79.Univ Calif San Diego, Ctr Behav Genet Aging, La Jolla, CA USA 80.Boston Univ, Dept Psychol Brain Sci, Boston, MA USA 81.Washington Univ, Sch Med, Dept Radiol, St Louis, MO USA 82.Vet Integrated Serv Network 17, Ctr Excellence Res Returning War Vet, Waco, TX USA 83.Baylor Univ, Dept Psychol & Neurosci, Waco, TX USA 84.Univ Texas Dallas, Sch Behav & Brain Sci, Ctr Vital Longev, Dallas, TX USA 85.Texas A&M Univ, Dept Psychiat & Behav Sci, Hlth Sci Ctr, Bryan, TX USA 86.Univ Minnesota, Dept Pediat, Minneapolis, MN USA 87.Mason Inst Developing Brain, Minneapolis, MN USA 88.Baylor Coll Med, Dept Psychiat, Houston, TX USA 89.Yale Univ, Dept Psychiat, Sch Med, New Haven, CT USA 90.Yale Univ, Dept Comparat Med, Wu Tsai Inst, New Haven, CT USA 91.Yale Univ, Dept Neurosci, Wu Tsai Inst, New Haven, CT USA 92.Yale Univ, Dept Psychol, Wu Tsai Inst, New Haven, CT USA 93.Natl Ctr PTSD, Div Clin Neurosci, West Haven, CT USA 94.Yale Univ, Wu Tsai Inst, Dept Psychiat, New Haven, CT USA 95.Univ Utah, Sch Med, Dept Neurol, Salt Lake City, UT USA 96.George E Wahlen Vet Affairs Med Ctr, Salt Lake City, UT USA 97.Virginia Commonwealth Univ, Dept Phys Med & Rehabil, Richmond, VA USA 98.Vet Affairs VA Richmond Hlth Care, Richmond, VA USA 99.Baylor Coll Med, H Ben Taub Dept Phys Med & Rehabil, Houston, TX USA 100.Monash Univ, Cent Clin Sch, Dept Neurosci, Melbourne, Vic, Australia 101.Monash Univ, Monash Biomed Imaging, Melbourne, Vic, Australia |
推荐引用方式 GB/T 7714 | Huggins, Ashley A.,Baird, C. Lexi,Briggs, Melvin,et al. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup[J]. MOLECULAR PSYCHIATRY,2024:13. |
APA | Huggins, Ashley A..,Baird, C. Lexi.,Briggs, Melvin.,Laskowitz, Sarah.,Hussain, Ahmed.,...&Morey, Rajendra.(2024).Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup.MOLECULAR PSYCHIATRY,13. |
MLA | Huggins, Ashley A.,et al."Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup".MOLECULAR PSYCHIATRY (2024):13. |
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