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Range adaptive value representations in schizophrenia and major depression | |
Wang, Ling-ling1,2,3,4; Lui, Simon S. Y.5; So, Jane W. L.6; Hu, Hui-xin1,2,3,7; Chu, Min-yi8; Cheng, Koi-Man6; Li, Shuai-biao8; Le, Bei-lin1,2,3; Lv, Qin-yu8,9; Yi, Zheng-hui8,10; Chan, Raymond C. K.1,2,3,11 | |
第一作者 | Ling-ling Wang |
通讯作者邮箱 | rckchan@psych.nc.cn (r.c.k. chan) |
心理所单位排序 | 1 |
摘要 | Anhedonia and amotivation are core symptoms of schizophrenia (SCZ) and major depressive disorder (MDD). Reward processing involves constructing and contrasting the representations for expected value (EV) and outcome value (OV) of a given stimulus, a phenomenon termed range adaptation. Impaired range adaptation can lead to anhedonia and amotivation. This study aimed to examine range adaptation in SCZ patients and MDD patients. Fifty SCZ, 46 MDD patients and 56 controls completed the Effort-based Pleasure Experience Task to measure EV and OV adaptation. SCZ and MDD patients showed altered range adaptation, albeit in different patterns. SCZ patients exhibited over-adaptation to OV and reduced adaptation to EV. By contrast, MDD patients exhibited diminished OV adaptation but intact EV adaptation. Both OV and EV adaptation were correlated with anhedonia and amotivation in SCZ and MDD. Taken together, our findings suggest that range adaptation is altered in both SCZ and MDD patients. Associations of OV and EV adaptation with anhedonia and amotivation were consistently found in SCZ and MDD patients. Impaired range adaptation in SCZ and MDD patients may be putative neural mechanisms and potential intervention targets for anhedonia and amotivation. |
关键词 | Range adaptation Reward processing Anhedonia Amotivation Transdiagnostic |
2024-02-01 | |
语种 | 英语 |
DOI | 10.1016/j.ajp.2023.103880 |
发表期刊 | ASIAN JOURNAL OF PSYCHIATRY |
ISSN | 1876-2018 |
卷号 | 92页码:8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX3415CX] ; National Key Research and Development Program[2016YFC0906402] ; Philip K. H. Wong Foundation |
出版者 | ELSEVIER |
WOS关键词 | REWARD ; PLEASURE ; DEFICITS ; SCALE ; METAANALYSIS ; ADAPTATION ; MOTIVATION |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:001152913600001 |
WOS分区 | Q1 |
资助机构 | Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; National Key Research and Development Program ; Philip K. H. Wong Foundation |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46919 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Shanghai Normal Univ, Sch Psychol, Shanghai, Peoples R China 5.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China 6.Castle Peak Hosp, Hong Kong, Peoples R China 7.Beijing Forestry Univ, Sch Humanities & Social Sci, Dept Psychol, Beijing, Peoples R China 8.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China 9.Fudan Univ, Huashan Hosp, Dept Psychiat, Shanghai, Peoples R China 10.Fudan Univ, Inst Mental Hlth, Shanghai, Peoples R China 11.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室; 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Wang, Ling-ling,Lui, Simon S. Y.,So, Jane W. L.,et al. Range adaptive value representations in schizophrenia and major depression[J]. ASIAN JOURNAL OF PSYCHIATRY,2024,92:8. |
APA | Wang, Ling-ling.,Lui, Simon S. Y..,So, Jane W. L..,Hu, Hui-xin.,Chu, Min-yi.,...&Chan, Raymond C. K..(2024).Range adaptive value representations in schizophrenia and major depression.ASIAN JOURNAL OF PSYCHIATRY,92,8. |
MLA | Wang, Ling-ling,et al."Range adaptive value representations in schizophrenia and major depression".ASIAN JOURNAL OF PSYCHIATRY 92(2024):8. |
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