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Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-na?ve patients with major depressive disorder | |
Wu, Yuxuan1,2; Zhao, Xueli2; Li, Zhe2; Yang, Ruchang1,2; Peng, Ruijie1,2; Zhou, Yue2,3; Xia, Xingzhi2,3; Deng, Hanxu2,3; Zhang, Xiaobin2; Du, Xiangdong1,2; Zhang, Xiangyang4 | |
第一作者 | Yuxuan Wu |
通讯作者邮箱 | xiangdong-du@163.com (xiangdong du) ; zhangxy@psych.ac.cn (xiangyang zhang) |
摘要 | Background Major depressive disorder (MDD) is a common psychiatric disorder worldwide. Psychotic depression has been reported to be frequently under-diagnosed due to poor recognition of psychotic features. Therefore, the purpose of this study was to reveal the rate and risk factors of psychotic symptoms in young, drugnaive patients with major depressive disorder at the time of their first episode.Methods A total of 917 patients were recruited and divided into psychotic and non-psychotic subgroups based on the Positive and Negative Syndrome Scale (PANSS) positive subscale score. Anxiety symptoms and depressive symptoms were measured by the Hamilton Anxiety Rating Scale (HAMA) and the 17-item Hamilton Depression Rating Scale (HAMD-17), respectively. Several biochemical indicators such as total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were also measured.Results The rate of psychotic symptoms among young adult MDD patients was 9.1%. There were significant differences in TSH (p<0.001), FBG (p<0.001), TC (p<0.0001), TG (p = 0.001), HDL-C (p = 0.049), LDL-C (p = 0.010), diastolic blood pressure (DP) (p<0.001), systolic blood pressure (SP) (p<0.001), and HAMD total score (p<0.001) between young MDD patients with and without psychotic depression. HAMD, TSH, TC, and severe anxiety were independently associated with psychotic symptoms in young adult MDD patients. In addition, among young MDD patients, the rate of suicide attempts in the psychotic subgroup was much higher than in the non-psychotic subgroup (45.8% vs. 16.9%).Conclusions Our findings suggest that psychotic symptoms are common in young MDD patients. Several clinical variables and biochemical indicators are associated with the occurrence of psychotic symptoms in young MDD patients. |
关键词 | First-episode psychosis Major depressive disorder Psychotic symptoms Young adults |
2024-01-23 | |
语种 | 英语 |
DOI | 10.1186/s12888-024-05517-5 |
发表期刊 | BMC PSYCHIATRY |
卷号 | 24期号:1页码:10 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Suzhou Gusu Health Talents Scientific Research Project |
出版者 | BMC |
WOS关键词 | CLINICAL-PRACTICE ; SUICIDE ; CHALLENGES ; CHILDREN ; ANXIETY ; SCALE ; EPIDEMIOLOGY ; ADIPONECTIN ; ADOLESCENTS ; BEHAVIORS |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:001148343700004 |
WOS分区 | Q2 |
资助机构 | Suzhou Gusu Health Talents Scientific Research Project |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46957 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Du, Xiangdong; Zhang, Xiangyang |
作者单位 | 1.Soochow Univ, Med Coll, Suzhou, Peoples R China 2.Soochow Univ, Suzhou Guangji Hosp, Guangji Hosp, Suzhou, Peoples R China 3.Xuzhou Med Univ, Xuzhou, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wu, Yuxuan,Zhao, Xueli,Li, Zhe,et al. Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-na?ve patients with major depressive disorder[J]. BMC PSYCHIATRY,2024,24(1):10. |
APA | Wu, Yuxuan.,Zhao, Xueli.,Li, Zhe.,Yang, Ruchang.,Peng, Ruijie.,...&Zhang, Xiangyang.(2024).Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-na?ve patients with major depressive disorder.BMC PSYCHIATRY,24(1),10. |
MLA | Wu, Yuxuan,et al."Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-na?ve patients with major depressive disorder".BMC PSYCHIATRY 24.1(2024):10. |
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