Disrupted brain networks underlying high-fidelity memory retrieval in subjective cognitive decline: A task-based fMRI study

doi:10.1002/alz.14431

PSYCH OpenIR

	Disrupted brain networks underlying high-fidelity memory retrieval in subjective cognitive decline: A task-based fMRI study
	Tang, Wei 1,2; Zeng, Qinghe 1,2; Xie, Kaiqi 1,2; Cui, Xiaoyu 1,2; Jin, Xinhu 1,2; Han, Ying 3,4,5,6,7,8; Li, Juan 1,2
通讯作者	Li, Juan(lijuan@psych.ac.cn)
摘要	INTRODUCTIONSubjective cognitive decline (SCD) is linked to memory complaints and disruptions in certain brain regions identified by molecular imaging and resting-state functional magnetic resonance imaging studies. However, it remains unclear how these regions interact to contribute to both subjective and potential objective memory issues in SCD.METHODSTo address this gap, task-based imaging studies are essential. The Mnemonic Similarity Task assessed high-fidelity retrieval meanwhile MRI data measured group differences in activation and functional connectivity (FC) (calculated by generalized psychophysiological Interaction) between SCD individuals and normal controls.RESULTSWorse high-fidelity retrieval in SCD was associated with hypoactivation in the hippocampus, hyperactivation in the control network (CN), and reduced FC between the hippocampus and CN. The angular gyrus (AG) partially drives this disconnection.DISCUSSIONThis study confirms objective cognitive deficits in SCD and highlights the AG's failure to integrate, addressing a gap in the literature that has primarily focused on the hippocampus and CN.Highlights Objective high-fidelity retrieval deficits detected in older adults with SCD. Dysfunctional neural activations within retrieval networks impair memory accuracy. Reduced task-based FC drives high-fidelity retrieval deficits. The SCD-related disruption of integrative function partly explains such deficits. Future studies may benefit from inspections on obstruction in cognitive process.
关键词	generalized psychophysiological interaction high-fidelity retrieval information transmission integrating region mnemonic similarity task subjective cognitive decline task fMRI
	2024-12-28
语种	英语
DOI	10.1002/alz.14431
发表期刊	ALZHEIMERS & DEMENTIA
ISSN	1552-5260
页码	13
收录类别	SCI
资助项目	National Natural Science Foundation of China ; National Key Research and Development Program of China[2020YFC2003000] ; National Key Research and Development Program of China[2018YFC2000300] ; National Key Research and Development Program of China[2018YFC2001701] ; National Key Research and Development Program of China[2022ZD0211800] ; National Key Research and Development Program of China[M-0759] ; Shenzhen Bay Scholars Program ; [32271121] ; [32071079] ; [82020108013] ; [82327809]
出版者	WILEY
WOS关键词	FUNCTIONAL CONNECTIVITY ; PATTERN SEPARATION ; PREFRONTAL CORTEX ; EPISODIC MEMORY ; RECOLLECTION ; IMPAIRMENT ; FRAMEWORK ; MATTER ; ADULTS
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology
WOS记录号	WOS:001385086700001
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Shenzhen Bay Scholars Program
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/47266
通讯作者	Li, Juan
作者单位	1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China 4.Hainan Univ, Sch Biomed Engn, State Key Lab Digital Med Engn, Key Lab Biomed Engn Hainan Prov, Sanya, Hainan, Peoples R China 5.Shenzhen Bay Lab, Inst Biomed Engn, Shenzhen, Peoples R China 6.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China 7.Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China 8.Cent Hosp Karamay, Xinjiang, Peoples R China
推荐引用方式 GB/T 7714	Tang, Wei,Zeng, Qinghe,Xie, Kaiqi,et al. Disrupted brain networks underlying high-fidelity memory retrieval in subjective cognitive decline: A task-based fMRI study[J]. ALZHEIMERS & DEMENTIA,2024:13.
APA	Tang, Wei.,Zeng, Qinghe.,Xie, Kaiqi.,Cui, Xiaoyu.,Jin, Xinhu.,...&Li, Juan.(2024).Disrupted brain networks underlying high-fidelity memory retrieval in subjective cognitive decline: A task-based fMRI study.ALZHEIMERS & DEMENTIA,13.
MLA	Tang, Wei,et al."Disrupted brain networks underlying high-fidelity memory retrieval in subjective cognitive decline: A task-based fMRI study".ALZHEIMERS & DEMENTIA (2024):13.