Institutional Repository of Key Laboratory of Behavioral Science, CAS
Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder | |
Chen, Zhenzhu1,2,3; Zhang, Zhifang1,2; Li, Feng1,2,3; Zhao, Lei1,2,3; Bo, Qijing1,2,3; Zhou, Yuan1,2,5,6; Wang, Chuanyue1,2,3,4 | |
第一作者 | Zhenzhu Chen |
通讯作者邮箱 | bqj718@163.com (qijing bo) ; zhouyuan@psych.ac.cn (yuan zhou) |
心理所单位排序 | 5 |
摘要 | Background: Bipolar disorder (BD) is a complex mental illness characterized by different mood states, including depression, mania/hypomania, and euthymia. This study aimed to comprehensively evaluate dynamic changes in intrinsic brain activity by using dynamic fractional amplitude of low-frequency fluctuations (dfALFF) and dynamic degree centrality (dDC) in patients with BD euthymia or depression and healthy individuals. Methods: The resting-state functional magnetic resonance imaging data were analyzed from 37 euthymic and 28 depressed patients with BD, as well as 85 healthy individuals. Using the sliding-window method, the dfALFF and dDC were calculated for each participant. These values were compared between the 3 groups using one-way analysis of variance (ANOVA). Additional analyses were conducted using different window lengths, step width, and window type to ensure the reliability of the results. Results: The euthymic group showed significantly lower dfALFF and dDC values of the left and right cerebellum posterior lobe compared with the depressed and control groups (cluster level P-FWE < 0.05), while the latter two groups were comparable. Brain regions showing significant group differences in the dfALFF analysis overlapped with those with significant differences in the dDC analysis. These results were consistent across different window lengths, step width, and window type. Conclusions: These findings suggested that patients with euthymic BD exhibit less flexibility of temporal functional activities in the cerebellum posterior lobes compared to either depressed patients or healthy individuals. These results could contribute to the development of neuropathological models of BD, ultimately leading to improved diagnosis and treatment of this complex illness. |
关键词 | Bipolar disorder Resting-state fMRI Dynamic fractional amplitude of low-frequency fluctuations Dynamic degree centrality Cerebellum posterior lobe |
2024-02-19 | |
语种 | 英语 |
DOI | 10.1186/s12888-024-05596-4 |
发表期刊 | BMC PSYCHIATRY |
卷号 | 24期号:1页码:10 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China |
出版者 | BMC |
WOS关键词 | LOW-FREQUENCY FLUCTUATION ; FUNCTIONAL TOPOGRAPHY ; UNIPOLAR DEPRESSION ; FRACTIONAL AMPLITUDE ; COGNITIVE IMPAIRMENT ; CENTRALITY ; FMRI |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:001174717500001 |
WOS分区 | Q2 |
资助机构 | National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/47270 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Bo, Qijing; Zhou, Yuan |
作者单位 | 1.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China 3.Capital Med Univ, Beijing Anding Hosp, Beijing Inst Brain Disorders Ctr Schizophrenia, Ctr Schizophrenia, Beijing 100088, Peoples R China 4.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100069, Peoples R China 5.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Chen, Zhenzhu,Zhang, Zhifang,Li, Feng,et al. Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder[J]. BMC PSYCHIATRY,2024,24(1):10. |
APA | Chen, Zhenzhu.,Zhang, Zhifang.,Li, Feng.,Zhao, Lei.,Bo, Qijing.,...&Wang, Chuanyue.(2024).Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder.BMC PSYCHIATRY,24(1),10. |
MLA | Chen, Zhenzhu,et al."Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder".BMC PSYCHIATRY 24.1(2024):10. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Decreased dynamic va(2325KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论