Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study

doi:10.1038/s41380-024-02877-y

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	Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study
	Di, Yazheng 1,2; Rahmani, Elior 3; Mefford, Joel 4; Wang, Jinhan 5; Ravi, Vijay 5; Gorla, Aditya 6; Alwan, Abeer 5; Kendler, Kenneth S.7,8; Zhu, Tingshao 1,2; Flint, Jonathan 9
通讯作者	Zhu, Tingshao(tszhu@psych.ac.cn) ; Flint, Jonathan(JFlint@mednet.ucla.edu)
摘要	Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in a multisite case-control cohort study of Chinese women with recurrent depression. Sixteen features were replicated in an independent cohort, with absolute association coefficients (beta values) from the combined analysis ranging from 0.24 to 1.07, indicating moderate to large effects. The statistical significance of these associations remained robust, with P values ranging from 7.2 x 10-6 to 6.8 x 10-58. Eleven features were significantly associated with current depressive symptoms. Using genotype data, we found that this association was driven in part by a genetic correlation with MDD. Significant voice features, reflecting a slower pitch change and a lower pitch, achieved an AUC-ROC of 0.90 (sensitivity of 0.85 and specificity of 0.81) in MDD classification. Our results return vocal features to a more central position in clinical and research work on MDD.
	2024-12-31
语种	英语
DOI	10.1038/s41380-024-02877-y
发表期刊	MOLECULAR PSYCHIATRY
ISSN	1359-4184
页码	10
收录类别	SCI
资助项目	National Institute of Mental Health[R01-MH122596] ; Wellcome Trust[200176/A/15/Z] ; Philanthropic donation from Shirley and Walter Wang
出版者	SPRINGERNATURE
WOS关键词	STRESSFUL LIFE EVENTS ; CLINICAL-FEATURES ; ACOUSTIC MEASURES ; CHINESE WOMEN ; SEVERITY ; RISK ; ONSET
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS类目	Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS记录号	WOS:001387247700001
资助机构	National Institute of Mental Health ; Wellcome Trust ; Philanthropic donation from Shirley and Walter Wang
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/47272
通讯作者	Zhu, Tingshao; Flint, Jonathan
作者单位	1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Univ Calif Los Angeles, Dept Computat Med, Los Angeles, CA USA 4.Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA USA 5.Univ Calif Los Angeles, Dept Elect & Comp Engn, Los Angeles, CA USA 6.Univ Calif Los Angeles, Bioinformat Interdept Program, Los Angeles, CA 90024 USA 7.Virginia Inst Psychiat & Behav Genet, Richmond, VA USA 8.Virginia Commonwealth Univ, Sch Med, Dept Psychiat, Richmond, VA USA 9.Univ Calif Los Angeles, Brain Res Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
推荐引用方式 GB/T 7714	Di, Yazheng,Rahmani, Elior,Mefford, Joel,et al. Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study[J]. MOLECULAR PSYCHIATRY,2024:10.
APA	Di, Yazheng.,Rahmani, Elior.,Mefford, Joel.,Wang, Jinhan.,Ravi, Vijay.,...&Flint, Jonathan.(2024).Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study.MOLECULAR PSYCHIATRY,10.
MLA	Di, Yazheng,et al."Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study".MOLECULAR PSYCHIATRY (2024):10.