Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia

doi:10.1016/j.ajp.2023.103892

	Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia
	Huang, Bingjie 1,2,3,4; Pu, Chengcheng 1,2,3,4; Guo, Xiaodong1,2,3,4 ; Chan, Raymond C. K.5,6 ; Huang, Jia5,6 ; Yu, Xin 1,2,3,4
通讯作者	Huang, Jia(huangj@psych.ac.cn) ; Yu, Xin(yuxin@bjmu.edu.cn)
摘要	Background: Patients with schizophrenia present difficulties in humor recognition and appreciation, but the neural mechanism of these deficits remains unclear. This study aimed to elucidate neural substrates underlying humor processing in patients with first episode schizophrenia (FES). Methods: This study recruited 40 patients with FES (illness duration <= 4 years) and 31 healthy controls matching for age, gender and education level. Participants completed a fMRI verbal humor processing paradigm comprising 96 stories, half for funny punch-line condition and the other half for unfunny condition. Participants were required to judge whether the story was funny or not. Signal detection theory (SDT) analysis was used to calculate d' and beta values which represented sensitivity and inner criteria for humor signals respectively. The funny-unfunny contrast was analyzed to identify the brain regions related with humor processing. d' and beta values were put into the imaging regression analysis. Results: Patients with FES showed significantly lower hit rate and sensitivity of humor signals (d'). At the neural level, patients with FES hypo-activated in ventral medial prefrontal cortex (vmPFC) and anterior cingulate cortex (ACC) while hyper-activated in middle temporal gyrus (MTG) and superior temporal gyrus (STG) compared to controls. In addition, activity in vmPFC and ACC was positively associated with d' and beta values, while activity in STG was positively associated with beta values in the clinical group. Conclusions: Patients with FES exhibited decreased sensitivity to humor signals. Hypo-activation in frontal re-gions and hyper-activation in temporal regions were associated with the humor processing deficits.
关键词	First episode schizophrenia Humor processing Functional magnetic resonance imaging
	2024-02-01
语种	英语
DOI	10.1016/j.ajp.2023.103892
发表期刊	ASIAN JOURNAL OF PSYCHIATRY
ISSN	1876-2018
卷号	92 页码:6
收录类别	SCI
资助项目	National Science Fund China[82171500] ; Key Program of Beijing Science and Technology Commission[D171100007017002] ; Capital's Funds for Health Improvement and Research (CFH)[2018-4-4116]
出版者	ELSEVIER
WOS关键词	ANTERIOR CINGULATE CORTEX ; COGNITIVE CONTROL ; SOCIAL COGNITION ; NEURAL CIRCUIT ; VERBAL JOKES ; EMOTION ; COMPREHENSION ; DEFICITS ; FMRI ; APPRECIATION
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:001165863800001
资助机构	National Science Fund China ; Key Program of Beijing Science and Technology Commission ; Capital's Funds for Health Improvement and Research (CFH)
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/47279
专题	中国科学院心理健康重点实验室
通讯作者	Huang, Jia; Yu, Xin
作者单位	1.Peking Univ Sixth Hosp, Beijing, Peoples R China 2.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China 3.Peking Univ, NHC Key Lab Mental Hlth, Beijing, Peoples R China 4.Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
通讯作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Huang, Bingjie,Pu, Chengcheng,Guo, Xiaodong,et al. Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2024,92:6.
APA	Huang, Bingjie,Pu, Chengcheng,Guo, Xiaodong,Chan, Raymond C. K.,Huang, Jia,&Yu, Xin.(2024).Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,92,6.
MLA	Huang, Bingjie,et al."Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 92(2024):6.