Thermal stimulus task fMRI in the cervical spinal cord at 7 Tesla | |
Seifert, Alan C.1,2,3,10; Xu, Junqian4,5; Kong, Yazhuo6,7; Eippert, Falk6,8; Miller, Karla L.6; Tracey, Irene6; Vannesjo, S. Johanna6,9 | |
第一作者 | Alan C. Seifert |
通讯作者邮箱 | alan.seifert@gmail.com (alan c. seifert) |
心理所单位排序 | 7 |
摘要 | Although functional magnetic resonance imaging (fMRI) is widely applied in the brain, fMRI of the spinal cord is more technically demanding. Proximity to the vertebral column and lungs results in strong spatial inhomogeneity and temporal fluctuations in B-0. Increasing field strength enables higher spatial resolution and improved sensitivity to blood oxygenation level-dependent (BOLD) signal, but amplifies the effects of B-0 inhomogeneity. In this work, we present the first task fMRI in the spinal cord at 7 T. Further, we compare the performance of single-shot and multi-shot 2D echo-planar imaging (EPI) protocols, which differ in sensitivity to spatial and temporal B-0 inhomogeneity. The cervical spinal cords of 11 healthy volunteers were scanned at 7 T using single-shot 2D EPI at 0.75 mm in-plane resolution and multi-shot 2D EPI at 0.75 and 0.6 mm in-plane resolutions. All protocols used 3 mm slice thickness. For each protocol, the BOLD response to 13 10-s noxious thermal stimuli applied to the right thumb was acquired in a 10-min fMRI run. Image quality, temporal signal to noise ratio (SNR), and BOLD activation (percent signal change and z-stat) at both individual- and group-level were evaluated between the protocols. Temporal SNR was highest in single-shot and multi-shot 0.75 mm protocols. In group-level analyses, activation clusters appeared in all protocols in the ipsilateral dorsal quadrant at the expected C6 neurological level. In individual-level analyses, activation clusters at the expected level were detected in some, but not all subjects and protocols. Single-shot 0.75 mm generally produced the highest mean z-statistic, while multi-shot 0.60 mm produced the best-localized activation clusters and the least geometric distortion. Larger than expected within-subject segmental variation of BOLD activation along the cord was observed. Group-level sensory task fMRI of the cervical spinal cord is feasible at 7 T with single-shot or multi-shot EPI. The best choice of protocol will likely depend on the relative importance of sensitivity to activation versus spatial localization of activation for a given experiment. |
关键词 | 7 T MRI fMRI spinal cord fMRI ultra-high field |
2024-02-15 | |
DOI | 10.1002/hbm.26597 |
发表期刊 | HUMAN BRAIN MAPPING |
ISSN | 1065-9471 |
卷号 | 45期号:3页码:14 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | H2020 European Research Council[K01NS105160] ; National Institutes of Health (NINDS)[W81XWH-17-1-0204] ; Department of Defense MSRP ; Max Planck Society ; European Research Council[758974] ; European Union[203139/Z/16/Z] ; European Union[2022] ; Wellcome Trust |
出版者 | WILEY |
WOS关键词 | PHYSIOLOGICAL NOISE ; FUNCTIONAL CONNECTIVITY ; 1.5 T ; PAIN ; STIMULATION ; MRI ; BRAIN ; ACTIVATION ; MOTOR ; VARIABILITY |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:001166565300001 |
WOS分区 | Q1 |
资助机构 | H2020 European Research Council ; National Institutes of Health (NINDS) ; Department of Defense MSRP ; Max Planck Society ; European Research Council ; European Union ; Wellcome Trust |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/47282 |
专题 | 认知与发展心理学研究室 |
通讯作者 | Seifert, Alan C. |
作者单位 | 1.Icahn Sch Med Mt Sinai, Biomed Engn & Imaging Inst, New York, NY USA 2.Icahn Sch Med Mt Sinai, Dept Diagnost Mol & Intervent Radiol, New York, NY USA 3.Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY USA 4.Baylor Coll Med, Dept Radiol, Houston, TX USA 5.Baylor Coll Med, Dept Psychiat, Houston, TX USA 6.Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Nuffield Dept Clin Neurosci, FMRIB, Oxford, England 7.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 8.Max Planck Inst Human Cognit & Brain Sci, Max Planck Res Grp Pain Percept, Leipzig, Germany 9.Norwegian Univ Sci & Technol NTNU, Dept Phys, Trondheim, Norway 10.1 Gustave L Levy Pl,Box 1234, New York, NY 10029 USA |
推荐引用方式 GB/T 7714 | Seifert, Alan C.,Xu, Junqian,Kong, Yazhuo,et al. Thermal stimulus task fMRI in the cervical spinal cord at 7 Tesla[J]. HUMAN BRAIN MAPPING,2024,45(3):14. |
APA | Seifert, Alan C..,Xu, Junqian.,Kong, Yazhuo.,Eippert, Falk.,Miller, Karla L..,...&Vannesjo, S. Johanna.(2024).Thermal stimulus task fMRI in the cervical spinal cord at 7 Tesla.HUMAN BRAIN MAPPING,45(3),14. |
MLA | Seifert, Alan C.,et al."Thermal stimulus task fMRI in the cervical spinal cord at 7 Tesla".HUMAN BRAIN MAPPING 45.3(2024):14. |
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