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Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis(Mar , 10.1007/s00787-023-02333-2, 2024)
Jin, Xingyue1,2; Zhang, Kun1,2; Lu, Bin3,4; Li, Xue5; Yan, Chao-Gan3,4; Du, Yasong6; Liu, Yi6; Lu, Jianping7; Luo, Xuerong1,2; Gao, Xueping1,2; Liu, Jing5
第一作者Jie Tang
通讯作者邮箱luoxuerong@csu.edu.cn (xuerong luo ) ; xuepinggao@csu.edu.cn (xueping gao) ; ljyuch@bjmu.edu.cn (jing liu )
心理所单位排序3
摘要

Schizophrenia and autism spectrum disorders (ASD) were considered as two neurodevelopmental disorders and had shared clinical features. we hypothesized that they have some common atypical brain functions and the purpose of this study was to explored the shared brain spontaneous activity strength alterations in early onset schizophrenia (EOS) and ASD in the children and adolescents with a multi-center large-sample study. A total of 171 EOS patients (aged 14.25 ± 1.87), 188 ASD patients (aged 9.52 ± 5.13), and 107 healthy controls (aged 11.52 ± 2.82) had scanned with Resting-fMRI and analyzed surface-based amplitude of low-frequency fuctuations (ALFF). Results showed that both EOS and ASD had hypoactivity in the primary sensorimotor regions (bilateral primary and early visual cortex, left ventral visual stream, left primary auditory cortex) and hyperactivity in the high-order transmodal regions (bilateral SFL, bilateral DLPFC, right frontal eye felds), and bilateral thalamus. EOS had more severe abnormality than ASD. This study revealed shared functional abnormalities in the primary sensorimotor regions and the high-order transmodal regions in EOS and ASD, which provided neuroimaging evidence of common changes in EOS and ASD, and may help with better early recognition and precise treatment for EOS and ASD.

关键词Schizophrenia  EOS  ASD  Autism fMRI  ALFF  Cortex
2024-03-06
语种英语
DOI10.1007/s00787-024-02409-7
发表期刊EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
ISSN1018-8827
页码1
期刊论文类型实证研究
收录类别SCI ; SSCI
出版者SPRINGER
WOS研究方向Psychology ; Pediatrics ; Psychiatry
WOS类目Psychology, Developmental ; Pediatrics ; Psychiatry
WOS记录号WOS:001177077900001
WOS分区Q1
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/47333
专题中国科学院行为科学重点实验室
通讯作者Luo, Xuerong; Gao, Xueping; Liu, Jing
作者单位1.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha 410011, Hunan, Peoples R China
2.Cent South Univ, Xiangya Hosp 2, Natl Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China
3.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
5.Peking Univ, Peking Univ Sixth Hosp, Peking Univ Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders,NHC Key Lab Men, 51 Huayuan Rd, Beijing 100191, Peoples R China
6.Shanghai Mental Hlth Ctr, 600 Wanping Nan Rd, Shanghai, Peoples R China
7.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child Psychiat, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Jin, Xingyue,Zhang, Kun,Lu, Bin,et al. Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis(Mar , 10.1007/s00787-023-02333-2, 2024)[J]. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY,2024:1.
APA Jin, Xingyue.,Zhang, Kun.,Lu, Bin.,Li, Xue.,Yan, Chao-Gan.,...&Liu, Jing.(2024).Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis(Mar , 10.1007/s00787-023-02333-2, 2024).EUROPEAN CHILD & ADOLESCENT PSYCHIATRY,1.
MLA Jin, Xingyue,et al."Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis(Mar , 10.1007/s00787-023-02333-2, 2024)".EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (2024):1.
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