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Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-na?ve patients with major depressive disorder comorbid with metabolic syndrome | |
Gao, Wenqi1; Deng, Zhifang2; Cai, Xiaonan1; Zhang, Dan3; Xiao, Han1; Zhang, Xiangyang4,5 | |
第一作者 | Wenqi Gao |
通讯作者邮箱 | tjxiaohan@hust.edu.cn (han xiao) ; zhangxy@psych.ac.cn (xiangyang zhang) |
摘要 | BackgroundAlthough gender differences in major depressive disorder (MDD) have been widely reported, there has not been much focus on gender differences in comorbidity. In patients with MDD and comorbid metabolic syndrome (Mets), the goal of this study was to investigate potential gender differences in the prevalence and clinical correlates of concomitant anxiety.MethodsSeven hundred and ninety-four first-episode and drug-naive patients (FEDN) patients with MDD and comorbid Mets were recruited. For each patient, sociodemographic data, thyroid function indicators, and Mets parameters were acquired. Each participant completed the 14-item Hamilton Assessment Scale for Anxiety (HAMA) and the 17-item Hamilton Assessment Scale for Depression (HAMD).ResultsThere were no gender differences in the prevalence of anxiety in patients with MDD and comorbid Mets. Female patients with MDD had a shorter duration of illness. Correlation analysis showed that HAMD score, TSH, TgAb, and TPOAb were associated with anxiety prevalence in female patients, whereas anxiety onset in male patients was only associated with TSH, TgAb, and TPOAb levels. In addition, multiple logistic regression analysis showed that TSH and TgAb predicted anxiety in male patients, whereas HAMD score and age of onset significantly predicted anxiety in female patients.LimitationsCross-sectional design and no control for anxiety-related factors.ConclusionsOur study showed no gender differences in the prevalence of anxiety in patients with MDD and comorbid Mets. HAMD score was associated with anxiety in female patients, whereas TSH, TgAb, and TPOAb were associated with anxiety in male patients. |
关键词 | Metabolic syndrome Anxiety First-episode and drug-naive major depressive disorder Chinese han Gender differences |
2024-02-22 | |
DOI | 10.1186/s12888-024-05574-w |
发表期刊 | BMC PSYCHIATRY |
卷号 | 24期号:1页码:8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China |
出版者 | BMC |
WOS关键词 | MENTAL-HEALTH SURVEY ; ANXIOUS DEPRESSION ; ASSOCIATION ; RISK ; SEX ; SCHIZOPHRENIA ; METAANALYSIS ; POPULATION ; DEFINITION ; SYMPTOMS |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:001172694800004 |
WOS分区 | Q2 |
资助机构 | National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/47345 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Xiao, Han; Zhang, Xiangyang |
作者单位 | 1.Huazhong Univ & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Inst Maternal & Child Hlth, Wuhan 430015, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Pharm, Wuhan 430030, Peoples R China 3.Huazhong Univ & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll,Woman Dept Community, Wuhan 430015, Hubei, Peoples R China 4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Gao, Wenqi,Deng, Zhifang,Cai, Xiaonan,et al. Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-na?ve patients with major depressive disorder comorbid with metabolic syndrome[J]. BMC PSYCHIATRY,2024,24(1):8. |
APA | Gao, Wenqi,Deng, Zhifang,Cai, Xiaonan,Zhang, Dan,Xiao, Han,&Zhang, Xiangyang.(2024).Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-na?ve patients with major depressive disorder comorbid with metabolic syndrome.BMC PSYCHIATRY,24(1),8. |
MLA | Gao, Wenqi,et al."Gender differences in prevalence and clinical correlates of anxiety in first-episode and drug-na?ve patients with major depressive disorder comorbid with metabolic syndrome".BMC PSYCHIATRY 24.1(2024):8. |
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