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| Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-na?ve major depressive disorder | |
Xia, Xingzhi1,2; Deng, Hanxu1,2; Ren, Wei2,3; Yang, Lin2,3; Zhu, Yingzhao2,3; Liu, Yaozhi2,4; Liu, Junjun5; Zhao, Xueli2; Jia, Fengnan2; Du, Xiangdong1,2; Zhang, Xiangyang6
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| 通讯作者 | Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 摘要 | IntroductionPsychotic depression (PD) is a highly debilitating disorder characterized by hallucinations and/or delusions accompanied by depression. A variety of neurotransmitters, hormones and corresponding receptors in the endocrine system are involved in the onset and progression of depression, and fasting blood glucose (FBG) can be an important indicator for monitoring the stability of the endocrine system. The aim of this study was to investigate the relationship between FBG and PD in a Chinese population with first-episode drug-na & iuml;ve (FEDN) major depressive disorder (MDD). MethodsIn this study, 1718 outpatient individuals diagnosed with first-episode drug-na & iuml;ve major depressive disorder (FEDN MDD) were included. The association between PD and FBG levels was identified through multivariable binary logistic regression analysis. To investigate potential non-linear relationships, a two-piecewise linear regression model was utilized. Additionally, interaction and stratified analyses were performed based on gender, educational background, marital status, presence of comorbid anxiety, and history of suicide attempt. ResultsMultivariate logistic regression analysis showed that FBG was positively associated with the risk of PD in FEDN MDD patients (OR = 1.68, 95% CI: 1.31 to 2.13; P < 0.05). Smoothed plots showed a non-linear relationship between FBG and PD, while the inflection point of FBG was calculated using a two-segmented logistic regression model to be 6.23 mmol/L. On the right side of the inflection point, the probability of PD increased substantially by 278% (OR = 3.78, 95% CI: 1.75 to 8.18, p < 0.001), while no significant association was observed on the left side of the inflection point (OR = 1.06, 95% CI: 0.73 to 1.52, p = 0.772). ConclusionsOur investigation revealed a nonlinear relationship between FBG and PD in patients with FEDN MDD, thereby informing more effective intervention strategies for managing psychotic symptoms in individuals with depression. |
| 关键词 | Major depressive disorder Fasting blood glucose (FBG) Psychotic symptom First episode Drug na & iuml ve |
| 2025-01-17 | |
| 语种 | 英语 |
| DOI | 10.1186/s12888-025-06502-2 |
| 发表期刊 | BMC PSYCHIATRY
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| 卷号 | 25期号:1页码:10 |
| 收录类别 | SCI |
| 资助项目 | Shanxi Medical University |
| 出版者 | BMC |
| WOS关键词 | DIABETES-MELLITUS ; HPA-AXIS ; SCALE ; RISK |
| WOS研究方向 | Psychiatry |
| WOS类目 | Psychiatry |
| WOS记录号 | WOS:001402000300001 |
| 资助机构 | Shanxi Medical University |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.psych.ac.cn/handle/311026/47543 |
| 专题 | 中国科学院心理健康重点实验室 |
| 通讯作者 | Du, Xiangdong; Zhang, Xiangyang |
| 作者单位 | 1.Xuzhou Med Univ, Xuzhou, Peoples R China 2.Soochow Univ, Suzhou Guangji Hosp, Guangji Hosp, Suzhou, Peoples R China 3.Soochow Univ, Med Coll, Suzhou, Peoples R China 4.North Sichuan Med Coll, Sch Psychiat, Nanchong, Sichuan, Peoples R China 5.Nanjing Meishan Hosp, Nanjing, Peoples R China 6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 通讯作者单位 | 中国科学院心理健康重点实验室 |
| 推荐引用方式 GB/T 7714 | Xia, Xingzhi,Deng, Hanxu,Ren, Wei,et al. Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-na?ve major depressive disorder[J]. BMC PSYCHIATRY,2025,25(1):10. |
| APA | Xia, Xingzhi.,Deng, Hanxu.,Ren, Wei.,Yang, Lin.,Zhu, Yingzhao.,...&Zhang, Xiangyang.(2025).Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-na?ve major depressive disorder.BMC PSYCHIATRY,25(1),10. |
| MLA | Xia, Xingzhi,et al."Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-na?ve major depressive disorder".BMC PSYCHIATRY 25.1(2025):10. |
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