Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report

doi:10.1016/j.jneuroim.2021.577667

	Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report
	Guo, Liyuan1,2 ; Ren, Haitao 3; Fan, Siyuan 3; Guan, Hongzhi 3; Wang, Jing1,2
第一作者	Guo, Liyuan
通讯作者邮箱	guanhz@263.net (h. guan) ; wangjing@psych.ac.cn (j. wang)
心理所单位排序	1
摘要	In the current study we report a novel autoantibody against Purkinje cells in a patient with primary autoimmune cerebellar ataxia (PACA) associated with Sjogren's syndrome (SS). Tissue-based indirect immunofluorescence assay (TBA) of the patient's serum and cerebrospinal fluid (CSF) revealed IgG antibody to Purkinje cells and the granular layer of the rat cerebellum. Rab6A was identified as autoantigen by mass spectrometry (MS) and Western blotting, and the interactions between Rab6A or its homologous Rab6B and autoantibody in patient serum were verified by recombinant cell-based assay (CBA) and neutralization experiments. This autoantibody may represent a novel biomarker in the diagnosis of PACA.
关键词	Autoimmune Cerebellar ataxia Novel autoantibody Anti-Rab6A Rab6B antibody
	2021-10-15
语种	英语
DOI	10.1016/j.jneuroim.2021.577667
发表期刊	JOURNAL OF NEUROIMMUNOLOGY
ISSN	0165-5728
卷号	359 页码:7
期刊论文类型	评论
URL	查看原文
收录类别	SCI
资助项目	National Key Research and Develop-ment Program of China[2016YFC0901500];CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
出版者	ELSEVIER
WOS关键词	MUTATIONS ; DISEASE ; WEAKNESS
WOS研究方向	Immunology ; Neurosciences & Neurology
WOS类目	Immunology ; Neurosciences
WOS记录号	WOS:000695211500008
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48216
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China; 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China; 3.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Guo, Liyuan,Ren, Haitao,Fan, Siyuan,et al. Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report[J]. JOURNAL OF NEUROIMMUNOLOGY,2021,359:7.
APA	Guo, Liyuan,Ren, Haitao,Fan, Siyuan,Guan, Hongzhi,&Wang, Jing.(2021).Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report.JOURNAL OF NEUROIMMUNOLOGY,359,7.
MLA	Guo, Liyuan,et al."Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report".JOURNAL OF NEUROIMMUNOLOGY 359(2021):7.