中国科学院心理健康重点实验室知识库

Background: To overcome the challenge of psychotherapist scarcity in applying pain psychotherapy in clinical practice, we developed a virtual reality (VR) program delivering weeks of pain psychotherapy without psychotherapists, with a focus on minimizing the risk of motion sickness. Objectives: We conducted a single-arm pilot study to assess the efficacy and motion sickness associated with a VR session delivering guided imagery and breathing techniques selected from the initial course of our VR program, involving patients suffering from various acute and chronic pain. Methods: Patients underwent a 15-min VR session. Pain-related and anxiety ratings using a 0-10 numerical rating scale were collected pre-, during-, post-VR and in 6-h follow-up. Motion sickness symptoms were assessed using Simulator Sickness Questionnaire pre- and post-VR. Results: Patients (n = 73) reported their perceived pain intensity and anxiety reduced significantly from pre- to post-VR by 22.9% and 45.0% (all p < 0.0001), respectively. Such modulatory effects of VR in pain perception and anxiety persisted at 30 min, 1 h, 2 h, and 6 h post-VR (all p < 0.0001). The pre-post beneficial effects of VR were independent from patients' demographic characteristics and their pain duration. Importantly, only six patients (8.2%) had post-VR motion sickness symptoms, and only one patient reported moderate level of severity. Conclusion: These findings suggest the selected VR session delivering pain psychotherapeutic techniques may be effective and tolerable for patients with varying pain conditions, which provides initial evidence for the development of future randomized controlled trials of the complete VR program.