Clinical risk factors of long-term post-traumatic stress symptoms, anxiety, and depression in COVID-19 survivors

doi:10.1007/s00406-024-01947-0

PSYCH OpenIR

	Clinical risk factors of long-term post-traumatic stress symptoms, anxiety, and depression in COVID-19 survivors
	Xiao, Yian 1,2; Zhang, Libo 1,2; Yang, Quanqi 1,2; Pan, Xinyu 1,2; Lu, Zhijie 3; Bi, Yanzhi 1,2; Hu, Li 1,2
通讯作者	Bi, Yanzhi(biyz@psych.ac.cn)
摘要	The COVID-19 pandemic has a profound and lasting impact on the mental health of recovered individuals. To investigate the clinical risk factors associated with long-term post-traumatic stress symptoms (PTSS), anxiety, and depression in COVID-19 survivors, demographic information and medical records were collected during February 19 and March 20, 2020. Assessments of PTSS, anxiety, and depressive symptoms were conducted at two months (April to May 2020, Session 1) and two years (April to May 2022, Session 2) post-discharge. Session 1 included 127 survivors who were infected with the early strains of SARS-CoV-2, and 54 of these participants took part in Session 2. PTSS (median: Session 1 = 9, Session 2 = 7; p = 0.522) and depression (median: Session 1 = 5, Session 2 = 4; p = 0.127) remained unchanged over the two years following COVID-19 infection, while anxiety (median: Session 1 = 5, Session 2 = 2; p < 0.001) significantly decreased at the two-year mark. Severe COVID-19 symptoms were consistently identified as significant risk factors for depression at both time points (Session 1: dyspnea [beta = -0.268, p = 0.016], nausea or vomiting [beta = 0.239, p = 0.031]; Session 2: headache [beta = 0.414, p = 0.014]). They also emerged as risk factors for PTSS and anxiety at the two-month mark (PTSS: cough [beta = -0.334, p = 0.002]; anxiety: continued oxygen therapy [beta = 0.343, p = 0.002], cough [beta = -0.267, p = 0.013]). At the two-year mark, blood sample characteristics were identified as risk factors for PTSS (albumin: beta = 0.455, p = 0.010), anxiety (total bilirubin: beta = 0.440, p = 0.013), and depression (total bilirubin: beta = 0.386, p = 0.021). Mann-Whitney U-tests showed that female survivors had higher anxiety (p = 0.012) and depression (p = 0.046) levels than males at the two-month mark. The sample size was relatively small, and further investigation is needed to determine whether our findings can be directly applied to other samples, including those involving different variants of SARS-CoV-2. Our study may highlight the differences between short-term and long-term clinical risk factors for PTSS, anxiety, and depression in COVID-19 survivors. The identified predictors could provide valuable insights for tailoring interventions to improve the PTSS, anxiety, and depression outcomes at different stages of recovery in COVID-19 survivors.
关键词	COVID-19 Post-traumatic stress symptom Anxiety Depression Risk factor
	2024-12-23
语种	英语
DOI	10.1007/s00406-024-01947-0
发表期刊	EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
ISSN	0940-1334
页码	10
收录类别	SCI
资助项目	National Natural Science Foundation of China[32071061] ; Beijing Natural Science Foundation[JQ22018]
出版者	SPRINGER HEIDELBERG
WOS关键词	MENTAL-HEALTH ; SEVERITY ; DISORDER
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:001390907600001
资助机构	National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48611
通讯作者	Bi, Yanzhi
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Shanghai Eastern Hepatobiliary Surg Hosp, Dept Anesthesiol, Shanghai 200438, Peoples R China
推荐引用方式 GB/T 7714	Xiao, Yian,Zhang, Libo,Yang, Quanqi,et al. Clinical risk factors of long-term post-traumatic stress symptoms, anxiety, and depression in COVID-19 survivors[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2024:10.
APA	Xiao, Yian.,Zhang, Libo.,Yang, Quanqi.,Pan, Xinyu.,Lu, Zhijie.,...&Hu, Li.(2024).Clinical risk factors of long-term post-traumatic stress symptoms, anxiety, and depression in COVID-19 survivors.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,10.
MLA	Xiao, Yian,et al."Clinical risk factors of long-term post-traumatic stress symptoms, anxiety, and depression in COVID-19 survivors".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2024):10.