Duration of untreated psychosis and cognitive function in first-episode antipsychotic-na?ve schizophrenia: Evidence from auditory P300

doi:10.1016/j.pnpbp.2024.111202

PSYCH OpenIR

	Duration of untreated psychosis and cognitive function in first-episode antipsychotic-na?ve schizophrenia: Evidence from auditory P300
	Lu, Chenghao 1,2; Li, Shaobing 1,2; Liu, Nannan 1,2; Li, Tongxin 1,2; Li, Yanzhe 1,2; Wang, Xinxu 1,2; Li, Shen 1,2; Li, Jie 1; Zhang, Xiang Yang 3,4
通讯作者	Li, Shen(lishen@tmu.edu.cn) ; Li, Jie(jieli@tjmhc.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
摘要	Objective: The relationship between the duration of untreated psychosis (DUP) and cognitive function in schizophrenia (SZ) patients remains debated, with no empirical evidence from event-related potential (ERP) studies supporting their association. This study aims to investigate the relationship between DUP and cognitive functions, as well as psychiatric symptoms, in first-episode antipsychotic-na & iuml;ve SZ (FEAN-SZ) patients using ERP. Methods: The study included 321 Chinese FEAN-SZ patients and 146 healthy controls. The DUP and sociodemographic characteristics of all participants were collected, and psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale. The P300 (P3) components, including P3a, P3b and N100, were recorded from all participants using auditory oddball paradigm. Results: 25.5 % of patients did not receive timely treatment for over four years, and those with lower educational levels or more severe negative symptoms had longer DUP (p = 0.027, p = 0.020). Compared to healthy controls, FEAN-SZ patients exhibited longer latencies and lower amplitudes in the P3 components (all p(s) < 0.001). Significant differences in the P3 components were observed among three groups of DUP (< 8 months, 8 to 48 months, and >= 48 months) (all p(s) < 0.001). In the 8 <= DUP < 48 months group, the N1 amplitude and P3a latency predicted positive symptom scores and general psychopathology scores, respectively (beta = -0.165, p = 0.037; beta = 0.541, p < 0.001); P3b latency predicted negative symptom scores in the DUP < 8 months group (beta = 0.391, p < 0.001). N1 amplitude predicted general psychopathology scores only in the DUP > 48 months group (beta = -0.228, p = 0.040). Multiple linear regression analysis indicated that the latency and amplitude of P3a were independently associated with DUP (B = 0.124, p < 0.001; B = -1.161, p = 0.012). Conclusions: SZ patients who have a longer DUP exhibit more severe P3 deficits, and the P3 components may be indicative of different psychiatric symptom severity in DUPs of different lengths, as well as the P3a component may serve as an electrophysiologic marker to assess the length of DUP.
关键词	Duration of untreated psychosis Schizophrenia First-episode antipsychotic-na & iuml Event-related potential P300 ve
	2025-01-10
语种	英语
DOI	10.1016/j.pnpbp.2024.111202
发表期刊	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN	0278-5846
卷号	136 页码:8
收录类别	SCI
资助项目	National Key Research and Develop-ment Program of China[2023YFF1203700] ; National Natural Science Foundation of China[82371512] ; Tianjin Health Research Project[TJWJ2024MS037]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	EARLY INTERVENTION ; 1ST EPISODE ; METAANALYSIS ; AMPLITUDE ; ILLNESS ; IMPACT ; CHINA ; TRIAL ; RISK
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目	Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:001396986800001
资助机构	National Key Research and Develop-ment Program of China ; National Natural Science Foundation of China ; Tianjin Health Research Project
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48645
通讯作者	Li, Shen; Li, Jie; Zhang, Xiang Yang
作者单位	1.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, 13 Liulin Rd, Tianjin 300222, Peoples R China 2.Tianjin Med Univ, Tianjin Anding Hosp, Brain Assessment & Intervent Lab, Mental Hlth Ctr, Tianjin 300222, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Lu, Chenghao,Li, Shaobing,Liu, Nannan,et al. Duration of untreated psychosis and cognitive function in first-episode antipsychotic-na?ve schizophrenia: Evidence from auditory P300[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2025,136:8.
APA	Lu, Chenghao.,Li, Shaobing.,Liu, Nannan.,Li, Tongxin.,Li, Yanzhe.,...&Zhang, Xiang Yang.(2025).Duration of untreated psychosis and cognitive function in first-episode antipsychotic-na?ve schizophrenia: Evidence from auditory P300.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,136,8.
MLA	Lu, Chenghao,et al."Duration of untreated psychosis and cognitive function in first-episode antipsychotic-na?ve schizophrenia: Evidence from auditory P300".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 136(2025):8.