Altered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa

doi:10.1002/erv.3172

PSYCH OpenIR

	Altered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa
	Wang, Yu-ping 1; Chu, Min-Yi 1; Wang, Yi 2,3; Lei, Xiaoxia 1; Kang, Qing 1; Yue, Ling 1; Chen, Yan 1; Lui, Simon S. Y.4; Wang, Zhen 1; Chan, Raymond C. K.1,2,3; Chen, Jue 1
通讯作者	Chen, Jue(chenjue2088@163.com)
摘要	ObjectiveAnorexia nervosa (AN) is associated with disturbances in reward processing, cognitive control, and body image perception, implicating striatal dysfunction. Evidence suggests that underweight may modulate brain function in AN. We aimed to investigate whole-brain resting-state functional connectivity (rsFC) of the striatum in patients with AN while controlling for the acute effects of underweight.MethodUsing theoretically selected striatal sub-regions, whole-brain rsFC patterns of the striatum were compared among patients with AN (n = 39, BMI = 16.19 +/- 1.48 kg/m2), normal weight healthy controls (NHC) (n = 31, BMI = 20.98 +/- 1.72 kg/m2), and underweight healthy controls (UHC) (n = 22, BMI = 16.68 +/- 0.69 kg/m2). Correlation analysis between rsFC and clinical measures was conducted for the patients with AN.ResultsCompared with the NHC group, AN patients showed increased striatal rsFC with the fronto-parietal network (FPN) and reduced striatal rsFC with sensorimotor and visual regions. Compared with the UHC group, AN patients exhibited reduced striatal rsFC solely with sensorimotor and visual regions. No significant correlations were found between striatal rsFC and clinical variables in the patients with AN.ConclusionOur findings suggest that decreased striatal rsFC with sensorimotor and visual areas may represent illness-specific neural correlates in patients with AN.
关键词	anorexia nervosa eating disorders neuroimaging resting-state functional connectivity striatum
	2025-01-16
语种	英语
DOI	10.1002/erv.3172
发表期刊	EUROPEAN EATING DISORDERS REVIEW
ISSN	1072-4133
页码	11
收录类别	SCI
资助项目	the Shanghai Jiao Tong University, key program of combination of engineering with medicine[82471573] ; National Natural Science Foundation ; Science and Technology Commission of Shanghai[20Y11906500] ; Municipality Medical Innovation Research Special Project[19MC1911100] ; Shanghai Clinical Research Center for Mental Health Foundation[YG2022ZD026] ; Shanghai Jiao Tong University[SHDC12023122] ; Shanghai Hospital Development Center, Emerging Frontier Technology Joint Research Project of Municipal Hospitals
出版者	WILEY
WOS关键词	STATE FUNCTIONAL CONNECTIVITY ; EATING-DISORDERS ; BRAIN ; REWARD
WOS研究方向	Psychology ; Psychiatry
WOS类目	Psychology, Clinical ; Psychiatry
WOS记录号	WOS:001396896000001
资助机构	the Shanghai Jiao Tong University, key program of combination of engineering with medicine ; National Natural Science Foundation ; Science and Technology Commission of Shanghai ; Municipality Medical Innovation Research Special Project ; Shanghai Clinical Research Center for Mental Health Foundation ; Shanghai Jiao Tong University ; Shanghai Hospital Development Center, Emerging Frontier Technology Joint Research Project of Municipal Hospitals
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48648
通讯作者	Chen, Jue
作者单位	1.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China 2.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci NACN Lab, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yu-ping,Chu, Min-Yi,Wang, Yi,et al. Altered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa[J]. EUROPEAN EATING DISORDERS REVIEW,2025:11.
APA	Wang, Yu-ping.,Chu, Min-Yi.,Wang, Yi.,Lei, Xiaoxia.,Kang, Qing.,...&Chen, Jue.(2025).Altered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa.EUROPEAN EATING DISORDERS REVIEW,11.
MLA	Wang, Yu-ping,et al."Altered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa".EUROPEAN EATING DISORDERS REVIEW (2025):11.