The neurophysiological mechanisms of medial prefrontal-perirhinal cortex circuit mediating temporal order memory decline in early stage of AD rats

doi:10.1016/j.nbd.2024.106584

PSYCH OpenIR

	The neurophysiological mechanisms of medial prefrontal-perirhinal cortex circuit mediating temporal order memory decline in early stage of AD rats
	Zhuo, Linan 1,2,3; Pang, Keliang 4,5,6; Dai, Jiajie 1,2; Wu, Bing 3; Wang, Jiesi 1; Xu, Hang 1; Yang, Shuming 7; Liu, Ziao 3; Niu, Rongrong 3; Yu, Ping 3; Wang, Weiwen 1,2
通讯作者	Yu, Ping(pingyu@cnu.edu.cn) ; Wang, Weiwen(wangww@psych.ac.cn)
摘要	The temporal component of episodic memory has been recognized as a sensitive behavioral marker in early stage of Alzheimer's disease (AD) patients. However, parallel studies in AD animals are currently lacking, and the underlying neural circuit mechanisms remain poorly understood. Using a novel AppNL-G-F knock-in (APP-KI) rat model, the developmental changes of temporal order memory (TOM) and the relationship with medial prefrontal cortex and perirhinal cortex (mPFC-PRH) circuit were determined through in vivo electrophysiology and microimaging technique. We observed a deficit in TOM performance during the object temporal order memory task (OTOMT) in APP-KI rats at 6 month old, which was not evident at 3 or 4 months of age. Alongside behavioral changes, we identified a gradually extensive and aggravated regional activation and functional alterations in the mPFC and PRH during the performance of OTOMT, which occurred prior to the onset of TOM deficits. Moreover, coherence analysis showed that the functional connectivity between the mPFC and PRH could predict the extent of future behavioral performance. Further analysis revealed that the aberrant mPFC-PRH interaction mainly attributed to the progressive deterioration of synaptic transmission, information flow and network coordination from mPFC to PRH, suggesting the mPFC dysfunction maybe the key area of origin underlying the early changes of TOM. These findings identify a pivotal role of the mPFC-PRH circuit in mediating the TOM deficits in the early stage of AD, which holds promising clinical translational value and offers potential early biological markers for predicting AD memory progression.
关键词	Alzheimer's disease rat Medial prefrontal cortex Perirhinal cortex Temporal order memory Neural oscillation
	2024-09-01
语种	英语
DOI	10.1016/j.nbd.2024.106584
发表期刊	NEUROBIOLOGY OF DISEASE
ISSN	0969-9961
卷号	199 页码:15
收录类别	SCI
资助项目	National Natural Science Foundation of China[82071517] ; National Natural Science Foundation of China[U21A20364] ; National Natural Science Foundation of China[31771217] ; National Key Research and Development Program of China[2017YFE0126500] ; Scientific Foundation of Institute of Psy-chology, Chinese Academy of Sciences[E2CX4115CX]
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	ALZHEIMERS-DISEASE ; RECOGNITION MEMORY ; EPISODIC MEMORY ; OSCILLATIONS ; HIPPOCAMPUS ; SEQUENCES ; OBJECTS ; BETA
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:001362107600001
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Scientific Foundation of Institute of Psy-chology, Chinese Academy of Sciences
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48759
通讯作者	Yu, Ping; Wang, Weiwen
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning & Cognit, Baiduizi Jia 23,Fuwai St, Beijing 100048, Peoples R China 4.Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Aging & Longev Inst, Shanghai 200032, Peoples R China 6.Fudan Univ, Zhongshan Hosp, Inst Biol Sci, Shanghai 200032, Peoples R China 7.Sun Yat Sen Univ, Div Clin Med, Zhongshan Sch Med, Guangzhou 510062, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhuo, Linan,Pang, Keliang,Dai, Jiajie,et al. The neurophysiological mechanisms of medial prefrontal-perirhinal cortex circuit mediating temporal order memory decline in early stage of AD rats[J]. NEUROBIOLOGY OF DISEASE,2024,199:15.
APA	Zhuo, Linan.,Pang, Keliang.,Dai, Jiajie.,Wu, Bing.,Wang, Jiesi.,...&Wang, Weiwen.(2024).The neurophysiological mechanisms of medial prefrontal-perirhinal cortex circuit mediating temporal order memory decline in early stage of AD rats.NEUROBIOLOGY OF DISEASE,199,15.
MLA	Zhuo, Linan,et al."The neurophysiological mechanisms of medial prefrontal-perirhinal cortex circuit mediating temporal order memory decline in early stage of AD rats".NEUROBIOLOGY OF DISEASE 199(2024):15.