A transdiagnostic approach of negative symptoms in psychiatric disorders: replication of a two-factor structure in major depressive disorder and bipolar disorder

doi:10.1007/s00406-024-01934-5

PSYCH OpenIR

	A transdiagnostic approach of negative symptoms in psychiatric disorders: replication of a two-factor structure in major depressive disorder and bipolar disorder
	Li, Shuai-Biao 1; Zhang, Jian-Biao 2; Liu, Chao 2; Wang, Ling-Ling 3,4,5; Hu, Hui-Xin 3,4,6; Chu, Min-Yi 1; Wang, Yi 3,4; Lv, Qin-Yu 1,7; Lui, Simon S. Y.8; Yi, Zheng-Hui 1,7,9; Chan, Raymond C. K.3,4
通讯作者	Yi, Zheng-Hui(yizhenghui1971@163.com) ; Chan, Raymond C. K.(rckchan@psych.ac.cn)
摘要	Recent empirical findings suggest that negative symptoms are not limited to schizophrenia (SCZ) but also present in major depressive disorder (MDD) and bipolar disorder (BD) patients. Although SCZ patients generally showed a latent structure comprising the motivation and pleasure (MAP) and expression (EXP) factors, it remains unclear whether the same latent structure exists in MDD and BD patients. We administered the Clinical Assessment Interview for Negative Symptoms (CAINS) and the Brief Negative Symptom Scale (BNSS) to 179 MDD patients and 152 BD patients. Confirmatory Factor Analysis (CFA) was conducted to examine the one-factor model, the two-factor model of the MAP and the EXP domain, the five-factor model of anhedonia, avolition, asociality, alogia, and blunted affect, and the hierarchical model comprising the first-order five-factor, and the second-order two-factor (MAP and EXP factors). We further examined the correlations between demographics and the negative symptom dimensions found in the best factor model. The CFA showed that, when the CAINS and the BNSS were combined together, the two-factor model of MAP and EXP provided the best model fit than other competing models, in the MDD alone sample, BD alone sample, and the combined clinical sample. The two-factor model of the MAP and EXP appears to be a stable, transdiagnostic latent structure of negative symptoms across BD and MDD. Clarifying negative symptoms in MDD and BD can facilitate future research on the underlying neural mechanisms of the MAP and EXP dimensions.
关键词	Negative symptoms Transdiagnostic Latent structure Major depressive disorder Bipolar disorder
	2024-11-02
语种	英语
DOI	10.1007/s00406-024-01934-5
发表期刊	EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
ISSN	0940-1334
页码	12
收录类别	SCI
资助项目	Jiangsu Provincial Key Research and Development Program
出版者	SPRINGER HEIDELBERG
WOS关键词	CLINICAL-ASSESSMENT INTERVIEW ; OF-FIT INDEXES ; SCHIZOPHRENIA ; SCALE ; INDIVIDUALS ; DIMENSIONS ; VALIDITY ; APATHY
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:001346174300002
资助机构	Jiangsu Provincial Key Research and Development Program
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48855
通讯作者	Yi, Zheng-Hui; Chan, Raymond C. K.
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, 600 South Wanping Rd, Shanghai, Peoples R China 2.Nantong Fourth Peoples Hosp, Nantong, Jiangsu, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Shanghai Normal Univ, Sch Psychol, Shanghai, Peoples R China 6.Beijing Forestry Univ, Sch Humanities & Social Sci, Dept Psychol, Beijing, Peoples R China 7.Fudan Univ, Huashan Hosp, Sch Med, Dept Psychiat, Shanghai, Peoples R China 8.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China 9.Fudan Univ, Inst Mental Hlth, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Li, Shuai-Biao,Zhang, Jian-Biao,Liu, Chao,et al. A transdiagnostic approach of negative symptoms in psychiatric disorders: replication of a two-factor structure in major depressive disorder and bipolar disorder[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2024:12.
APA	Li, Shuai-Biao.,Zhang, Jian-Biao.,Liu, Chao.,Wang, Ling-Ling.,Hu, Hui-Xin.,...&Chan, Raymond C. K..(2024).A transdiagnostic approach of negative symptoms in psychiatric disorders: replication of a two-factor structure in major depressive disorder and bipolar disorder.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,12.
MLA	Li, Shuai-Biao,et al."A transdiagnostic approach of negative symptoms in psychiatric disorders: replication of a two-factor structure in major depressive disorder and bipolar disorder".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2024):12.