Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia

doi:10.1016/j.schres.2024.10.015

PSYCH OpenIR

	Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia
	Li, Shaobing 1,2; Lu, Chenghao 1; Liu, Nannan 1,2; Li, Yanzhe 1,2; Wang, Xinxu 1,2; Li, Shen 1,2; Li, Jie 1; Zhang, Xiang Yang 3,4
通讯作者	Li, Shen(lishen@tmu.edu.cn) ; Li, Jie(jieli@tjmhc.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
摘要	Objective: Suicidal thoughts and behaviors (STBs) are critical concern in schizophrenia (SZ). Concurrent changes in event-related potential (ERP), particularly the P300 (P3) components, have been observed in SZ patients, but the association between these changes and STBs remains unclear. This study aims to explore the relationships between P3 components and STBs in first-episode antipsychotic-na & iuml;ve SZ (FEAN-SZ) patients. Methods: The study included 321 FEAN-SZ patients and 146 healthy controls (HC). Sociodemographic data, clinical assessments, and ERP P3 components (N1, P3a, and P3b) were collected. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), while depressive symptoms were evaluated with the Hamilton Depression Scale (HAMD). Results: Compared to HC, FEAN-SZ patients exhibited lower N1 and P3 amplitudes and longer latencies (all p(s) < 0.001). Patients with STBs exhibited higher scores on negative, general psychopathology, PANSS total and HAMD, decreased N1 and P3a amplitudes, as well as prolonged P3a and P3b latencies compared to those without STBs (all p(s) < 0.001). The P3a latency predicted the general psychopathology scores ((3 = 0.103, p < 0.001), and the N1 amplitude predicted the HAMD scores ((3 = -1.057, p = 0.001), both exclusively within the STBs group. Logistic regression analysis identified that N1 amplitude (Beta = -0.132, p = 0.018, OR = 1.02, 95%CI = 1.01-1.04) and HAMD scores (Beta = 0.068, p = 0.001, OR = 1.07, 95%CI = 1.03-1.11) as independent predictors of STBs in FEAN-SZ patients. Combining these variables yielded an area under the receiver operating characteristic (AUCROC) curve of 0.840 for distinguishing between patients with and without STBs. Conclusions: FEAN-SZ patients with STBs have lower P3 amplitude and longer latency. The N1 amplitude and depressive levels are associated with STBs in FEAN-SZ patients. The N1 amplitude may serve as an early biological marker for STBs in SZ patients.
关键词	Schizophrenia First-episode antipsychotic-na & iuml Suicide Event-related potential P300 Depression ve
	2024-12-01
语种	英语
DOI	10.1016/j.schres.2024.10.015
发表期刊	SCHIZOPHRENIA RESEARCH
ISSN	0920-9964
卷号	274 页码:352-359
收录类别	SCI
资助项目	National Natural Science Foundation of China[82371512] ; National Key Research and Development Program of China[2023YFF1203700] ; Tianjin Health Research Project[TJWJ2024MS037]
出版者	ELSEVIER
WOS关键词	MAJOR DEPRESSIVE DISORDER ; RISK-FACTORS ; METAANALYSIS ; PREVALENCE ; MORTALITY ; BIOMARKER
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:001347185600001
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Tianjin Health Research Project
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48864
通讯作者	Li, Shen; Li, Jie; Zhang, Xiang Yang
作者单位	1.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, Tianjin 300222, Peoples R China 2.Tianjin Med Univ, Tianjin Anding Hosp, Brain Assessment & Intervent Lab, Mental Hlth Ctr, Tianjin 300222, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Shaobing,Lu, Chenghao,Liu, Nannan,et al. Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2024,274:352-359.
APA	Li, Shaobing.,Lu, Chenghao.,Liu, Nannan.,Li, Yanzhe.,Wang, Xinxu.,...&Zhang, Xiang Yang.(2024).Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia.SCHIZOPHRENIA RESEARCH,274,352-359.
MLA	Li, Shaobing,et al."Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia".SCHIZOPHRENIA RESEARCH 274(2024):352-359.