Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia

doi:10.1016/j.brainres.2024.149282

PSYCH OpenIR

	Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia
	Li, Shen 1,2; Liu, Nannan 1,2; Qi, Dan 1,2; Niu, Lichao 1,2; Li, Yanzhe 1,2; Lu, Chenghao 1,2; Dong, Yeqing 1,2; Wang, Xinxu 1,2; Li, Jie 1; Zhang, Xiangyang 3,4
通讯作者	Li, Jie(jieli@tjmhc.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
摘要	Background: First-episode antipsychotics-na & iuml;ve schizophrenia (FEAN-SCZ) is associated with abnormalities in glucose and lipid metabolism. While sex differences in the incidence and severity of SCZ and metabolic abnormalities have been documented, the specific metabolic abnormalities between the sexes remain unclear. The study aimed to investigate sex-specific differences in plasma glycolipid profiles in FEAN-SCZ patients. Methods: A total of 172 FEAN-SCZ patients (male/female: 83/89) and 31 healthy controls (male/female: 14/17) were recruited. Psychopathology assessment was conducted using the Positive and Negative Syndrome Scale (PANSS). Glycolipid profiles, including oral glucose tolerance test (OGTT), fasting glucose, insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were examined in all participants. Results: FEAN patients displayed significantly higher fasting and 2-hour glucose levels compared to healthy controls (both p < 0.001). Impaired glucose tolerance (IGT) prevalence in male patients was 24.1 % (n = 20) and 25.9 % (n = 23) in females, contrasting with 0 % (n = 0) in the control group. FEAN patients exhibited elevated blood insulin and TC levels (both p < 0.05) and increased insulin resistance measured by HOMA-IR (p < 0.01). Among male patients, those with IGT had significantly higher TC, TG and LDL levels than non-IGT patients (all p < 0.05), while no significant differences were observed in female patients between IGT and non-IGT groups. Body mass index (BMI), TG and HDL levels were identified as significant predictors of IGT in male FEAN patients. Conclusions: IGT is present in a subset of FEAN-SCZ patients. Male patients with IGT exhibit distinct alterations in plasma lipid profiles compared to non-IGT patients.
关键词	Schizophrenia First-episode antipsychotics-naive Glycolipid metabolism OGTT Sex differences
	2025
语种	英语
DOI	10.1016/j.brainres.2024.149282
发表期刊	BRAIN RESEARCH
ISSN	0006-8993
卷号	1846 页码:7
收录类别	SCI
资助项目	National Natural Science Foundation of China[82371512] ; Tianjin Key Medical Discipline (Specialty) Con-struction Project[TJYXZDXK-033A] ; Tianjin Health Research Project for Young Scholars[TJWJ2021QN064]
出版者	ELSEVIER
WOS关键词	GENDER-DIFFERENCES ; PSYCHOSIS ; TOLERANCE ; INSULIN ; RISK ; METAANALYSIS ; ASSOCIATION ; PREVALENCE ; MECHANISMS ; MORTALITY
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:001343375500001
资助机构	National Natural Science Foundation of China ; Tianjin Key Medical Discipline (Specialty) Con-struction Project ; Tianjin Health Research Project for Young Scholars
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48894
通讯作者	Li, Jie; Zhang, Xiangyang
作者单位	1.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, Tianjin 300222, Peoples R China 2.Tianjin Med Univ, Tianjin Anding Hosp, Brain Assessment & Intervent Lab, Mental Hlth Ctr, Tianjin 300222, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Shen,Liu, Nannan,Qi, Dan,et al. Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia[J]. BRAIN RESEARCH,2025,1846:7.
APA	Li, Shen.,Liu, Nannan.,Qi, Dan.,Niu, Lichao.,Li, Yanzhe.,...&Zhang, Xiangyang.(2025).Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia.BRAIN RESEARCH,1846,7.
MLA	Li, Shen,et al."Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia".BRAIN RESEARCH 1846(2025):7.