A citrullinated antigenic vaccine in treatment of autoimmune arthritis

doi:10.1016/j.scib.2024.02.042

PSYCH OpenIR

	A citrullinated antigenic vaccine in treatment of autoimmune arthritis
	Jin, Xu 1,2,3; Dong, Tianya 4,5; Wang, Qian 2,6; Xie, Yang 1,2; Fang, Xiangyu 1,2; Wei, Chaonan 1,2; Liu, Shuyan 1,2; Zheng, Xi 1,2,3; Wang, Ping 1,2; Zhu, Danxue 1,2,3; Cao, Lulu 1,2; Dong, Suwei 2,6; Fang, Kechi 4,5; Zhong, Chao 7; Wang, Jing 4,5; Hu, Fanlei 1,2,8,9; Li, Zhanguo 1,2,3,9
通讯作者	Wang, Jing(wangjing@psych.ac.cn) ; Hu, Fanlei(fanleihu@bjmu.edu.cn) ; Li, Zhanguo(li99@bjmu.edu.cn)
摘要	Rheumatoid arthritis (RA) is an inflammatory autoimmune disease triggered by antigenic peptides with environmental and genetic risk factors. It has been shown that antigen-specific targeting could be a promising therapeutical strategy for RA by restoring immune tolerance to self-antigens without compromising normal immunity. Citrullination of antigens enhances antigenic properties and induces autoimmune responses. Here, we showed that citrullinated antigenic (citAg) vaccine ameliorated collagen-induced arthritis with decreased T-helper 1 (Th1) and Th17 cells, downregulated proinflammatory cytokines including interlukin-6 and tumor necrosis factor-alpha, and inhibited antigen recall responses. B cell receptor sequencing further revealed that citAg vaccine could dampen the dysregulated V(D)J recombination, restoring the immune repertoire. Taken together, the results demonstrated that citAg vaccine might have a therapeutic effect on RA. (c) 2024 Science China Press. Published by Elsevier B.V. and Science China Press. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
关键词	CitAg Citrullination Collagen type II Therapeutic vaccine Immune tolerance Rheumatoid arthritis
	2024-09-30
语种	英语
DOI	10.1016/j.scib.2024.02.042
发表期刊	SCIENCE BULLETIN
ISSN	2095-9273
卷号	69 期号:18 页码:2920-2929
收录类别	SCI
资助项目	Guangdong Basic and Applied Basic Research Foundation[2020B1515130005] ; National Nat-ural Science Foundation of China[82371807] ; National Nat-ural Science Foundation of China[82171773] ; National Nat-ural Science Foundation of China[92374202] ; National Nat-ural Science Foundation of China[32141004] ; National Key R&D Program of China[2022YFC3602000] ; Beijing Nova Program[Z181100006218044] ; Beijing Nova Program[Z211100002121163]
出版者	ELSEVIER
WOS关键词	RHEUMATOID-ARTHRITIS ; LUNGS ; SUPPRESSION ; TOLERANCE ; PROTEINS
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001318889200001
资助机构	Guangdong Basic and Applied Basic Research Foundation ; National Nat-ural Science Foundation of China ; National Key R&D Program of China ; Beijing Nova Program
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48986
通讯作者	Wang, Jing; Hu, Fanlei; Li, Zhanguo
作者单位	1.Peking Univ Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China 2.Beijing Key Lab Rheumatism Mech & Immune Diag, Beijing 100044, Peoples R China 3.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 6.Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, Beijing 100191, Peoples R China 7.Peking Univ, NHC Key Lab Med Immunol, Beijing Key Lab Tumor Syst Biol, Inst Syst Biomed,Dept Immunol,Hlth Sci Ctr, Beijing 100191, Peoples R China 8.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 9.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Jin, Xu,Dong, Tianya,Wang, Qian,et al. A citrullinated antigenic vaccine in treatment of autoimmune arthritis[J]. SCIENCE BULLETIN,2024,69(18):2920-2929.
APA	Jin, Xu.,Dong, Tianya.,Wang, Qian.,Xie, Yang.,Fang, Xiangyu.,...&Li, Zhanguo.(2024).A citrullinated antigenic vaccine in treatment of autoimmune arthritis.SCIENCE BULLETIN,69(18),2920-2929.
MLA	Jin, Xu,et al."A citrullinated antigenic vaccine in treatment of autoimmune arthritis".SCIENCE BULLETIN 69.18(2024):2920-2929.