Characterizing human spontaneous thoughts and its application in major depressive disorder

doi:10.1016/j.jad.2024.08.060

PSYCH OpenIR

	Characterizing human spontaneous thoughts and its application in major depressive disorder
	Li, Hui-Xian 1,2; Chen, Xiao 2,3; Wang, Zi-Han 2,3; Lu, Bin 2,3; Liao, Yi-Fan 2,3; Li, Xue-Ying 2,3; Wang, Yu-Wei 2,3; Liu, Yan-Song 4; Castellanos, Francisco Xavier 5,6; Yan, Chao-Gan 2,3,7
通讯作者	Yan, Chao-Gan(yancg@psych.ac.cn)
摘要	Background: Spontaneous thought is a universal, complex, and heterogeneous cognitive activity that significantly impacts mental activity and strongly correlates with mental disorders. Methods: Utilizing the think-aloud method, we captured spontaneous thoughts during rest from 38 diagnosed with depression, alongside 36 healthy controls and 137 healthy individuals. Through a comprehensive assessment of various dimensions of thought content, we compared thought content between individuals with depression and healthy controls, and between healthy women and men. Finally, we employed natural language processing (NLP) to develop regression models for multidimensional content assessment and a classification model to differentiate between individuals with and without depression. Results: Compared to healthy controls, individuals with depression had more internally oriented and less externally oriented spontaneous thoughts. They focused more on themselves and negative things, and less on positive things, experiencing higher levels of negative emotions and lower levels of positive emotions. Besides, we found that compared to healthy men, healthy women's spontaneous thoughts focus more on interoception, the self, past events, and negative events, and they experience higher levels of negative emotions. Meanwhile, we identified the potential application of the think-aloud method to collect spontaneous thoughts and integrate NLP in the field of depression. Conclusions: This study offers direct insights into the stream of thought during individuals' resting state, revealing differences between individuals with depression and healthy controls, as well as sex differences in the content of spontaneous thoughts. It enhances our understanding of spontaneous thought and offers a new perspective for preventing, diagnosing, and treating depression.
关键词	Depression Sex differences Resting-state spontaneous thought Think-aloud method Natural language processing
	2024-11-15
语种	英语
DOI	10.1016/j.jad.2024.08.060
发表期刊	JOURNAL OF AFFECTIVE DISORDERS
ISSN	0165-0327
卷号	365 页码:276-284
收录类别	SCI
资助项目	Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology[2021ZD0200600] ; National Key Research and Development Program of China[2017YFC1309902] ; National Natural Science Foundation of China[82122035] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; National Natural Science Foundation of China[32300933] ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Beijing Nova Program of Science and Technology[20230484465] ; Beijing Natural Science Foundation[J230040] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4425YZ] ; Postdoctoral Research Special Fund of the Third Affiliated Hospital of Zhengzhou University[2023080] ; China Scholarship Council (CSC)[202104910248]
出版者	ELSEVIER
WOS关键词	MIND WANDERS ; SEX-DIFFERENCES ; TIME
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:001301248600001
资助机构	Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Beijing Natural Science Foundation ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Postdoctoral Research Special Fund of the Third Affiliated Hospital of Zhengzhou University ; China Scholarship Council (CSC)
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49019
通讯作者	Yan, Chao-Gan
作者单位	1.Zhengzhou Univ, Affiliated Hosp 3, Zhengzhou, Peoples R China 2.Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing, Peoples R China 4.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou, Peoples R China 5.NYU, Robert I Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA 6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA 7.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Hui-Xian,Chen, Xiao,Wang, Zi-Han,et al. Characterizing human spontaneous thoughts and its application in major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2024,365:276-284.
APA	Li, Hui-Xian.,Chen, Xiao.,Wang, Zi-Han.,Lu, Bin.,Liao, Yi-Fan.,...&Yan, Chao-Gan.(2024).Characterizing human spontaneous thoughts and its application in major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,365,276-284.
MLA	Li, Hui-Xian,et al."Characterizing human spontaneous thoughts and its application in major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 365(2024):276-284.