Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project

doi:10.1016/j.ajp.2024.104202

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	Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project
	Zhang, Zhenqing 1,2; Huang, Bingjie 2; Wu, Weiwei 1,2; Ye, Xiaobin 3; Gao, Tianqi 2; Guo, Xiaodong 2; Yu, Xin 2; Wang, Yi 4,5; Pu, Chengcheng 2
通讯作者	Wang, Yi(wangyi@psych.ac.cn) ; Pu, Chengcheng(puchengcheng@bjmu.edu.cn)
摘要	Background: Schizophrenia is a heterogeneous psychotic disorder. Recent theories have emphasized the importance of interactions among psychiatric symptoms in understanding the pathological mechanisms of schizophrenia. In the current study, we examined the symptom network in patients with first-episode schizophrenia (FES) at four time points during a six-month follow-up period. Methods: In total, 565 patients with FES were recruited from the Chinese First-Episode Schizophrenia Trial (CNFEST) project. Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) at baseline and follow-up (514 patients at one month, 429 at three months, and 392 at six months). We used a network analysis approach to estimate symptom networks with individual symptoms as nodes and partial correlation coefficients between symptoms as edges. A cross-lagged panel network (CLPN) model was used to identify predictive pathways for clinical symptoms. Results: We found stable and strongly connected edges in patients across the time points, such as links between delusions and suspiciousness/persecution (P1:P6), and emotional withdrawal and passive/apathetic social withdrawal (N2:N4). Emotional withdrawal (N2), poor rapport (N3), and passive/apathetic social withdrawal (N4) had high centrality estimates across all four time points. CLPN analysis showed that negative symptoms, including emotional withdrawal (N2), poor rapport (N3), and passive/apathetic social withdrawal (N4), and stereotyped thinking (N7) may have predictive effects for negative and general symptoms at follow-ups. Conclusions: The symptom network of schizophrenia may be dynamic as treatment progresses. Negative symptoms remain the central and stable symptoms of schizophrenia. Negative symptoms may be potential therapeutic targets that predict other symptoms.
关键词	First-episode schizophrenia Negative symptoms Neurocognitive symptoms Network analysis
	2024-11-01
语种	英语
DOI	10.1016/j.ajp.2024.104202
发表期刊	ASIAN JOURNAL OF PSYCHIATRY
ISSN	1876-2018
卷号	101 页码:8
收录类别	SCI
资助项目	Xiamen Xianyue Hospital Foundation[2020XYYB05] ; National Science Fund China[82171500] ; Key Program of Beijing Science and Technology Commission[D171100007017002] ; Capital's Funds for Health Improvement and Research (CFH)[2018-4-4116] ; National Natural Science Foundation of China[31871114] ; CAS Key Laboratory of Mental Health, Institute of Psychology
出版者	ELSEVIER
WOS关键词	NEGATIVE SYMPTOMS ; PREDICTORS ; SCALE
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:001311808700001
资助机构	Xiamen Xianyue Hospital Foundation ; National Science Fund China ; Key Program of Beijing Science and Technology Commission ; Capital's Funds for Health Improvement and Research (CFH) ; National Natural Science Foundation of China ; CAS Key Laboratory of Mental Health, Institute of Psychology
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49076
通讯作者	Wang, Yi; Pu, Chengcheng
作者单位	1.Xiamen Xianyue Hosp, Xianyue Hosp, Fujian Psychiat Ctr, Fujian Clin Res Ctr Mental Disorders,Xiamen Med Co, Xiamen, Fujian, Peoples R China 2.Peking Univ, Peking Univ Sixth Hosp, Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental D, Beijing, Peoples R China 3.Zhangzhou Fourth Hosp, Zhangzhou, Fujian, Peoples R China 4.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhenqing,Huang, Bingjie,Wu, Weiwei,et al. Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project[J]. ASIAN JOURNAL OF PSYCHIATRY,2024,101:8.
APA	Zhang, Zhenqing.,Huang, Bingjie.,Wu, Weiwei.,Ye, Xiaobin.,Gao, Tianqi.,...&Pu, Chengcheng.(2024).Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project.ASIAN JOURNAL OF PSYCHIATRY,101,8.
MLA	Zhang, Zhenqing,et al."Dynamics of symptom network in patients with first-episode schizophrenia: Insight from the CNFEST project".ASIAN JOURNAL OF PSYCHIATRY 101(2024):8.