This study is a research on the stress of the secondary school students. The whole work included the construction of the Daily Hassle Scale of the Secondary School Students and the research on the mediate factors of the stressors. Six kinds of the daily hassle were found by the factor analysis: problem with academic performance, problem with school life, problem with teachers, problem with family, problem with heterosexual relation, problem with self-esteem. The reliability and validity of the scale is high. By the regression analysis of the SCL-90 score, we found that the factors which influence the physical and mental health of the secondary school students are the personal character(neuroticism, locus of control), daily hassle (problem with academic performance, problem with heterosexual relation) and age.