A型行为核心特征与血管紧张素转换酶基因型相关性研究
王择青
学位类型博士
1999
学位授予单位中国科学院心理研究所
学位授予地点中国科学院心理研究所
学位专业生理心理学
关键词A型行为 血管紧张素转换酶(ACE) 基因型
摘要为探讨A型行为特征有无遗传因素,本研究采用现代分子生物学的方法,以既与冠心病发病有密切关联,又与A型行为、社会心理应激等因素有密切关系的ACE基因作为靶基因,在北京及河北地区的人群中,对A型行为、ACE基因多态性与冠心病之间的关系进行了一系列的研究,分六个部分①首先对A型等为待征与血清ACE水平的相关进行了研究。结果表明:A型者血清ACE水平明显高于B型行为者,血清ACE水平值与A型行为问卷中CH分值具有极显著的相关性,与TH分值相关性不明显;②对A型行为特征与血清ACE水平的相关性进行了研究,结果表明:ACE基因I/C多态性存在明显的种族差异,中国人血清ACE水平与ACEDD基因表型及D等位基因呈明显正相关;③对ACE基因型与冠心病的相关性进行了研究,结果表明:ACE I/D 基因多态性是中国人冠心病发痛,尤其是发生心肌梗塞或冠脉多支血管病变的重要危险因子;④对A型行为特征与ACE基因型的相关性进行了研究,结果表明:ACE基因型与A型性格问卷中CH分量表所代表的“富于竞争精神、追求高成就、怀有戒心或敌意、性情急噪和缺乏耐心等A型行为特征”具有很好的相关性;⑤对A型行为特征、ACE基因型与冠心病的关系进行了探讨,结果表明:与ACE基因型具有相关性的A型行为特征是导致冠心病发病的重要因素之一;与ACE基因型在与冠心病发病的相关性趋向上是一致的。⑥将样本扩大到1306例后,我们对A型行为核心特征与ACE基因型的相关性进行了探讨,结果表明:在大样本的情况下,A型行为问卷的CH分量表分值与ACE基因型仍具有很好的相关性。进一步的研究发现:ACE基因型“缺乏耐心、易激惹、敌意”行为特征密切关联。本研究结果提示我们,ACE基因型有可能成为行为特征遗传研究中的有力工具。
其他摘要In order to study the role of inherited factors and Type A Behavior Pattern (TABP) in the development of CHD, the present study chose the angiotensin I-converting enzyme (ACE) gene as the target gene, and investigated the associations of TABP, the polymorphism of ACE gene with susceptibility to development of CHD in the healthy population and CHD patients from Northern China. 1. Correlation Analysis Between TABP and serum level of ACE in Chinese healthy individuals TABP and serum of ACE were determined in 137 Chinese healthy individuals. The results showed that there was a significant correlation between the scores of CH in TABP invertory and the serum level of ACE. 2 The distribution charicteristics of ACE gene polymorphism frequencies and association with serum level of ACE in Chinese healthy individuals population The polymorphism of ACE gene and serum of ACE were determined in 137 Chinese healthy individuals. The results showed that: the ethnic differences in I/D polymorphism of ACE gene are obvious; deletion polymorphism of the ACE gene is associated with serum ACE level. 3. The relationship between insertion/deletion polymorphism of ACE gene and CHD in a Chinese population I/D polymorphism in intron 16 of the ACE gene was determined by polymerase chain reaction(PCR) in a study of 109 patients with CHD. The results showed: The frequencies of DD genotype(0.39) and D allele(0.63) were higher among the CHD group than among the control subjects(0.12 and 0.42 respectively, P < 0.01). Furthermore, MI and multivessel disease was more strongly associated with (P < 0.01). It is indicated that D allele and DD gentype of ACE might be an important risk factor for CHD, especially for MI or multivessel disease in Chinese population. 4. Correlation Analysis Between Type A Behavior Pattern and the Polymorphism of ACE Gene The polymorphism of ACE gene and type A behavior pattern (TABP) survey were determined in 291 Chinese healthy individuals. The result showed that the higher frequency of rare D allele of an insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene was found in type A behavior individuals compared with type B behavior individuals in 291 healthy individuals; there was a significant correlation between the scores of CH in TABP invertory and DD genotype of the ACE gene. It is suggested that the behavioral attributes of competitiveness, achievement striving, hostility, being irritated easily and impatience may be associated with heredity. 5. Correlation Analysis Between Angiotensin I-Converting Enzyme Gene Polymorphism, Type A Behavior Pattern and Coronary Heart Disease in Chinese The polymorphism of ACE gene and type A behavior pattern (TABP) survey were determined in 109 patients with CHD. The results showed the development of coronary heart disease(CHD) is influenced mainly by the behavioral attributes of competitiveness, achievement striving, hostility, being irritated easily and impatience; the deletion polymorphism of ACE gene may be play a important role in the process of it. 6. Correlation Analysis Between Type A Behavior Pattern Core Components and the Polymorphism of ACE Gene The polymorphism of ACE gene and type A behavior pattern (TABP) survey were determined in1306 Chinese healthy individuals. The results showed that there was a significant correlation between the scores of CH in TABP invertory and DD genotype of the ACE gene. Furthermore, the behavioral attributes of hostility, being irritated easily and impatience may be associated with heredity. At the end of this research, in terms of theory, the research approaches of TABP and the factors influenced the relationship between TABP and CHD were explored and discussed. Furthermore, several new opinions were put forward.
页数100
语种中文
文献类型学位论文
条目标识符http://ir.psych.ac.cn/handle/311026/4924
专题中国科学院心理研究所回溯数据库(1956-2010)
推荐引用方式
GB/T 7714
王择青. A型行为核心特征与血管紧张素转换酶基因型相关性研究[D]. 中国科学院心理研究所. 中国科学院心理研究所,1999.
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