Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study

doi:10.1186/s12916-024-03443-7

PSYCH OpenIR

	Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study
	Li, Xingxing 1,2,3; Liu, Junyao 2,3; Wei, Shuochi 1; Yu, Chang 1; Wang, Dongmei 2,3; Li, Yuchen 1; Li, Jiaxin 2,3; Zhuang, Wenhao 1; Luo, Rui-Chen-Xi 1; Li, Yanli 1; Liu, Zhiwang 1; Su, Yuqiu 1; Liu, Jimeng 1; Xu, Yongming 1; Fan, Jialin 4; Zhu, Guidong 4; Xu, Weiqian 5; Tang, Yiping 5; Yan, Hui 5; Cho, Raymond Y.6; Kosten, Thomas R.6; Zhou, Dongsheng 1; Zhang, Xiangyang 2,3
通讯作者	Zhou, Dongsheng(wyzhouds@sina.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
摘要	Background Cognitive dysfunction is one of the common symptoms in patients with major depressive disorder (MDD). Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have been studied separately in the treatment of cognitive dysfunction in MDD patients. We aimed to investigate the effectiveness and safety of rTMS combined with tDCS as a new therapy to improve neurocognitive impairment in MDD patients. Methods In this brief 2-week, double-blind, randomized, and sham-controlled trial, a total of 550 patients were screened, and 240 MDD inpatients were randomized into four groups (active rTMS + active tDCS, active rTMS + sham tDCS, sham rTMS + active tDCS, sham rTMS + sham tDCS). Finally, 203 patients completed the study and received 10 treatment sessions over a 2-week period. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was performed to assess patients' cognitive function at baseline and week 2. Also, we applied the 24-item Hamilton Depression Rating Scale (HDRS-24) to assess patients' depressive symptoms at baseline and week 2. Results After 10 sessions of treatment, the rTMS combined with the tDCS group showed more significant improvements in the RBANS total score, immediate memory, and visuospatial/constructional index score (all p < 0.05). Moreover, post hoc tests revealed a significant increase in the RBANS total score and Visuospatial/Constructional in the combined treatment group compared to the other three groups but in the immediate memory, the combined treatment group only showed a better improvement than the sham group. The results also showed the RBANS total score increased significantly higher in the active rTMS group compared with the sham group. However, rTMS or tDCS alone was not superior to the sham group in terms of other cognitive performance. In addition, the rTMS combined with the tDCS group showed a greater reduction in HDRS-24 total score and a better depression response rate than the other three groups. Conclusions rTMS combined with tDCS treatment is more effective than any single intervention in treating cognitive dysfunction and depressive symptoms in MDD patients.
关键词	Major depressive disorder rTMS tDCS Clinical trial Cognition
	2024-06-20
语种	英语
DOI	10.1186/s12916-024-03443-7
发表期刊	BMC MEDICINE
ISSN	1741-7015
卷号	22 期号:1 页码:12
收录类别	SCI
资助项目	Natural Science Foundation of Zhejiang Province[LQ21H170001] ; Basic Public Welfare Project of Zhejiang Province[LGF22H090055] ; Ningbo Medical and Health brand discipline[PPXK2024-07] ; Ningbo Clinical Medical Research Centre for Mental Health[2022L002] ; Ningbo Top Medical and Health Research Program[2022030410] ; Zhejiang Medical and Health Science and Technology Plan Project[2021KY331] ; Ningbo Natural Science Foundation of China[202003N4263] ; Ningbo Natural Science Foundation of China[2021J275] ; Ningbo Natural Science Foundation of China[2019A610298] ; Zhejiang Province Traditional Chinese Medicine Health Project[2021ZB266] ; Ningbo Public Welfare Science and Technology Plan Project[2021S180] ; Ningbo Medical Science and Technology Project[2019Y24] ; Ningbo Medical Science and Technology Project[2020Y19] ; Ningbo Medical Science and Technology Project[2021Y25] ; Lishui Public Welfare Technology Application Research Project[2022GYX46]
出版者	BMC
WOS关键词	TRANSCRANIAL MAGNETIC STIMULATION ; NONINVASIVE BRAIN-STIMULATION ; CORTICAL EXCITABILITY ; PREFRONTAL CORTEX ; MOTOR CORTEX ; EFFICACY ; SCHIZOPHRENIA ; METAANALYSIS ; COMBINATION ; MODULATION
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
WOS记录号	WOS:001252151800001
资助机构	Natural Science Foundation of Zhejiang Province ; Basic Public Welfare Project of Zhejiang Province ; Ningbo Medical and Health brand discipline ; Ningbo Clinical Medical Research Centre for Mental Health ; Ningbo Top Medical and Health Research Program ; Zhejiang Medical and Health Science and Technology Plan Project ; Ningbo Natural Science Foundation of China ; Zhejiang Province Traditional Chinese Medicine Health Project ; Ningbo Public Welfare Science and Technology Plan Project ; Ningbo Medical Science and Technology Project ; Lishui Public Welfare Technology Application Research Project
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49298
通讯作者	Zhou, Dongsheng; Zhang, Xiangyang
作者单位	1.Ningbo Univ, Ningbo Kangning Hosp, Ningbo Key Lab Phys Diag & Treatment Mental & Psyc, Affiliated Kangning Hosp, Ningbo, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Second Peoples Hosp Lishui, Dept Geriatr, Lishui, Zhejiang, Peoples R China 5.Taizhou Second Peoples Hosp, Taizhou, Zhejiang, Peoples R China 6.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX USA
推荐引用方式 GB/T 7714	Li, Xingxing,Liu, Junyao,Wei, Shuochi,et al. Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study[J]. BMC MEDICINE,2024,22(1):12.
APA	Li, Xingxing.,Liu, Junyao.,Wei, Shuochi.,Yu, Chang.,Wang, Dongmei.,...&Zhang, Xiangyang.(2024).Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study.BMC MEDICINE,22(1),12.
MLA	Li, Xingxing,et al."Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study".BMC MEDICINE 22.1(2024):12.