Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain

doi:10.1016/j.neuroimage.2024.120877

PSYCH OpenIR

	Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain
	Chen, Min 1; Wu, Xiao 2,3,4; Zhang, Libo 3,4; Zhang, Fengrui 3,4; Li, Linling 5; Zhang, Yingying 6; Xiong, Donglin 7; Qiu, Yunhai 5; Hu, Li 3,4; Xiao, Weibo 7,8
通讯作者	Hu, Li(huli@psych.ac.cn) ; Xiao, Weibo(xiaoweibo820901@163.com)
摘要	Pain is a highly subjective and multidimensional experience, significantly influenced by various psychological factors. Placebo analgesia and nocebo hyperalgesia exemplify this influence, where inert treatments result in pain relief or exacerbation, respectively. While extensive research has elucidated the psychological and neural mechanisms behind these effects, most studies have focused on transient pain stimuli. To explore these mechanisms in the context of tonic pain, we conducted a study using a 15-minute tonic muscle pain induction procedure, where hypertonic saline was infused into the left masseter of healthy participants. We collected real-time Visual Analogue Scale (VAS) scores and functional magnetic resonance imaging (fMRI) data during the induction of placebo analgesia and nocebo hyperalgesia via conditioned learning. Our findings revealed that placebo analgesia was more pronounced and lasted longer than nocebo hyperalgesia. Real-time pain ratings correlated significantly with neural activity in several brain regions. Notably, the putamen was implicated in both effects, while the caudate and other regions were differentially involved in placebo and nocebo effects. These findings confirm that the tonic muscle pain paradigm can be used to investigate the mechanisms of placebo and nocebo effects and indicate that placebo analgesia and nocebo hyperalgesia may have more distinct than common neural bases.
关键词	Placebo analgesia Nocebo hyperalgesia Tonic muscle pain Functional magnetic resonance imaging (fMRI) Putamen Caudate
	2024-10-15
语种	英语
DOI	10.1016/j.neuroimage.2024.120877
发表期刊	NEUROIMAGE
ISSN	1053-8119
卷号	300 页码:13
收录类别	SCI
资助项目	National Key Research and Development Program of China[2023YFC2508702] ; National Natural Science Foundation of China[32071061] ; Beijing Natural Science Foundation[JQ22018] ; Medical Science and Technology Research Fund of Guangdong Province[A2021478] ; Hundred Talents Program of Chinese Academy of Sciences[Y14408] ; Shenzhen Science and Technology Program[JC201005270293A] ; Joint Laboratory for Basic Research of Neuropathic Pain[Y4Z050]
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	PARTIAL-REINFORCEMENT ; SOMATOSENSORY CORTEX ; CAUDATE-NUCLEUS ; FMRI ; HYPERALGESIA ; EXPERIENCE ; EXTINCTION ; INTENSITY ; PUTAMEN ; BRAIN
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:001330900900001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Medical Science and Technology Research Fund of Guangdong Province ; Hundred Talents Program of Chinese Academy of Sciences ; Shenzhen Science and Technology Program ; Joint Laboratory for Basic Research of Neuropathic Pain
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49311
通讯作者	Hu, Li; Xiao, Weibo
作者单位	1.Shenzhen Samii Med Ctr, Dept Anesthesiol, Shenzhen, Guangdong Provi, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Neural Engn, Shenzhen, Guangdong Provi, Peoples R China 6.Loudi Cent Hosp, Dept Neurol, Loudi, Hunan Province, Peoples R China 7.Nanshan Hosp Shenzhen City, Guangdong Med Coll, Dept Pain, Shenzhen, Guangdong Provi, Peoples R China 8.Loudi Cent Hosp, Dept Anesthesiol, Loudi, Hunan Province, Peoples R China
推荐引用方式 GB/T 7714	Chen, Min,Wu, Xiao,Zhang, Libo,et al. Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain[J]. NEUROIMAGE,2024,300:13.
APA	Chen, Min.,Wu, Xiao.,Zhang, Libo.,Zhang, Fengrui.,Li, Linling.,...&Xiao, Weibo.(2024).Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain.NEUROIMAGE,300,13.
MLA	Chen, Min,et al."Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain".NEUROIMAGE 300(2024):13.