Deciphering Authentic Nociceptive Thalamic in Rats

doi:10.34133/research.0348

PSYCH OpenIR

	Deciphering Authentic Nociceptive Thalamic in Rats
	Li, Zhenjiang 1,2; Zhang, Libo 1,2; Zhang, Fengrui 1,2; Yue, Lupeng 1,2; Hu, Li 1,2
通讯作者	Hu, Li(huli@psych.ac.cn)
摘要	The thalamus and its cortical connections play a pivotal role in pain information processing, yet the exploration of its electrophysiological responses to nociceptive stimuli has been limited. Here, in 2 experiments we recorded neural responses to nociceptive laser stimuli in the thalamic (ventral posterior lateral nucleus and medial dorsal nucleus) and cortical regions (primary somatosensory cortex [S1] and anterior cingulate cortex) within the lateral and medial pain pathways. We found remarkable similarities in laser-evoked brain responses that encoded pain intensity within thalamic and cortical regions. Contrary to the expected temporal sequence of ascending information flow, the recorded thalamic response (N1) was temporally later than its cortical counterparts, suggesting that it may not be a genuine thalamusgenerated response. Importantly, we also identified a distinctive component in the thalamus, i.e., the early negativity (EN) occurring around 100 ms after the onset of nociceptive stimuli. This EN component represents an authentic nociceptive thalamic response and closely synchronizes with the directional information flow from the thalamus to the cortex. These findings underscore the importance of isolating genuine thalamic neural responses, thereby contributing to a more comprehensive understanding of the thalamic function in pain processing. Additionally, these findings hold potential clinical implications, particularly in the advancement of closed-loop neuromodulation treatments for neurological diseases targeting this vital brain region.
	2024-04-09
语种	英语
DOI	10.34133/research.0348
发表期刊	RESEARCH
ISSN	2096-5168
卷号	7 页码:15
收录类别	SCI
资助项目	Beijing Natural Science Foundation[JQ22018] ; National Natural Science Foundation of China[32071061] ; STl2030-Major Projects[2022ZD0206400]
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS关键词	PRIMARY SOMATOSENSORY CORTEX ; ELECTROPHYSIOLOGICAL RESPONSES ; PAIN ; BRAIN ; OSCILLATIONS ; STIMULATION ; MEDIODORSAL ; NEURONS ; SIGNALS ; EEG
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001242424700001
资助机构	Beijing Natural Science Foundation ; National Natural Science Foundation of China ; STl2030-Major Projects
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49330
通讯作者	Hu, Li
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Zhenjiang,Zhang, Libo,Zhang, Fengrui,et al. Deciphering Authentic Nociceptive Thalamic in Rats[J]. RESEARCH,2024,7:15.
APA	Li, Zhenjiang,Zhang, Libo,Zhang, Fengrui,Yue, Lupeng,&Hu, Li.(2024).Deciphering Authentic Nociceptive Thalamic in Rats.RESEARCH,7,15.
MLA	Li, Zhenjiang,et al."Deciphering Authentic Nociceptive Thalamic in Rats".RESEARCH 7(2024):15.