The effect of cognitive impairment based on Mini-Mental State Examination (MMSE) on suicidal tendency in patients with schizophrenia: A large cross-sectional study

doi:10.1016/j.schres.2024.05.004

PSYCH OpenIR

	The effect of cognitive impairment based on Mini-Mental State Examination (MMSE) on suicidal tendency in patients with schizophrenia: A large cross-sectional study
	Zhu, Quanfeng 1; Jiang, Guojun 1; Zheng, Yali 1; Fu, Zhengchuang 1; Zhang, Peng 1; Zhang, Xiang -Yang 2,3,4
通讯作者	Zhang, Xiang -Yang(zhangxy@psych.ac.cn)
摘要	Background: The effect of cognitive function on suicidal tendency in patients with schizophrenia is still inconclusive. This study aimed to explore the effect of cognitive impairment on suicidal tendency in schizophrenia patients and the risk factors of suicidal tendency in schizophrenia patients with cognitive impairment. Methods: A total of 988 subjects were recruited for this study and finally 517 patients were included in the statistical analysis. Sociodemographic information was collected for each subject. Mini -Mental State Examination (MMSE) was used to assess patients' cognitive functioning. In addition, the Positive and Negative Syndrome Scale (PANSS) positive subscale, Insomnia Severity Index (ISI), and Beck Scale for Suicide Ideation (BSI) were used to assess psychotic symptoms, severity of insomnia, and intensity of suicidal ideation, respectively. Results: Schizophrenia patients with cognitive dysfunction were significantly less likely to develop suicidal tendencies than those without cognitive dysfunction (P < 0.05, OR = 0.58, 95%CI: 0.39-0.81). In patients with cognitive impairment, those with suicidal tendency had substantially higher scores on BSI, ISI, EC, PD, IRI, F1, and PANSS positive subscale, and took more types of antipsychotic drugs than those without suicidal tendency (all P < 0.05), and the results of binary logistic regression analysis showed that, PANSS positive subscale score (B = 0.06, p = 0.04, OR = 1.07, 95%CI: 1.00-1.13) was a risk factor for suicidal tendencies. Conclusions: Our findings suggest that schizophrenia patients with cognitive dysfunction are significantly less likely to develop suicidal tendencies. Moreover, positive symptom is a risk factor for suicidal tendencies in schizophrenia patients with cognitive dysfunction.
关键词	Schizophrenia Cognitive dysfunction Suicide MMSE-Mini Mental State Examination Positive symptom
	2024-07-01
语种	英语
DOI	10.1016/j.schres.2024.05.004
发表期刊	SCHIZOPHRENIA RESEARCH
ISSN	0920-9964
卷号	269 页码:48-55
收录类别	SCI
出版者	ELSEVIER
WOS关键词	FACIAL EMOTION RECOGNITION ; IDEATION ; RISK
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:001241630500001
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49339
通讯作者	Zhang, Xiang -Yang
作者单位	1.Hangzhou Normal Univ, Affiliated Xiaoshan Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Quanfeng,Jiang, Guojun,Zheng, Yali,et al. The effect of cognitive impairment based on Mini-Mental State Examination (MMSE) on suicidal tendency in patients with schizophrenia: A large cross-sectional study[J]. SCHIZOPHRENIA RESEARCH,2024,269:48-55.
APA	Zhu, Quanfeng,Jiang, Guojun,Zheng, Yali,Fu, Zhengchuang,Zhang, Peng,&Zhang, Xiang -Yang.(2024).The effect of cognitive impairment based on Mini-Mental State Examination (MMSE) on suicidal tendency in patients with schizophrenia: A large cross-sectional study.SCHIZOPHRENIA RESEARCH,269,48-55.
MLA	Zhu, Quanfeng,et al."The effect of cognitive impairment based on Mini-Mental State Examination (MMSE) on suicidal tendency in patients with schizophrenia: A large cross-sectional study".SCHIZOPHRENIA RESEARCH 269(2024):48-55.