Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China

doi:10.1186/s12888-024-05860-7

PSYCH OpenIR

	Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China
	Yang, Ruchang 1,2; Li, Zhe 2; Zhu, Yingzhao 1,2; Wu, Yuxuan 1,2; Lu, Xinchuan 2; Zhao, Xueli 2; Liu, Junjun 3; Du, Xiangdong 1,2; Zhang, Xiangyang 4
通讯作者	Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
摘要	Introduction Psychotic depression (PD) is characterized by the co-occurrence of emotional dysfunction and psychotic symptoms such as delusions and hallucinations with poor clinical outcomes. TSH may involve in the development of PD. This study aims to explore relationship between TSH and PD. Methods A total of 1718 outpatients diagnosed as FEDN MDD were recruited in this study. The relationship between PD and TSH was evaluated using multivariable binary logistic regression analysis. To assess the presence of non-linear associations, a two-piecewise linear regression model was employed. Furthermore, interaction and stratified analyses were conducted with respect to sex, education, marital status, comorbid anxiety, and suicide attempt. Results Multivariable logistic regression analysis revealed that TSH was positively associated with the risk of PD after adjusting for confounders (OR = 1.26, 95% CI: 1.11 to 1.43; p < 0.05). Smoothing plots showed a nonlinear relationship between TSH and PD, with the inflection point of TSH being 4.94 mIU/L. On the right of the inflection point, for each unit increase in serum TSH level on the right side of the inflection point, the probability of PD increased substantially by 47% (OR = 1.47, 95% CI: 1.25 to 1.73, p < 0.001), while no significant association was observed on the left side of the inflection point (OR = 0.87, 95% CI: 0.67 to 1.14, p = 0.32). Conclusion Our investigation showed a nonlinear TSH-PD relationship in FEDN MDD patients, thus contributing to effective intervention strategies for psychotic symptoms in depression patients.
关键词	Major depressive disorder Thyroid-stimulating hormone(TSH) Psychotic symptom First episode Drug naive
	2024-06-04
语种	英语
DOI	10.1186/s12888-024-05860-7
发表期刊	BMC PSYCHIATRY
卷号	24 期号:1 页码:9
收录类别	SCI
资助项目	Suzhou Gusu Health Talents Scientific Research Project ; Shanxi Medical University
出版者	BMC
WOS关键词	THYROID-FUNCTION ; PREVALENCE ; FEATURES ; ILLNESS ; SEROTONIN
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:001239285700010
资助机构	Suzhou Gusu Health Talents Scientific Research Project ; Shanxi Medical University
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49342
通讯作者	Du, Xiangdong; Zhang, Xiangyang
作者单位	1.Soochow Univ, Suzhou Med Coll, Suzhou, Peoples R China 2.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou, Peoples R China 3.Nanjing Meishan Hosp, Nanjing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yang, Ruchang,Li, Zhe,Zhu, Yingzhao,et al. Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China[J]. BMC PSYCHIATRY,2024,24(1):9.
APA	Yang, Ruchang.,Li, Zhe.,Zhu, Yingzhao.,Wu, Yuxuan.,Lu, Xinchuan.,...&Zhang, Xiangyang.(2024).Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China.BMC PSYCHIATRY,24(1),9.
MLA	Yang, Ruchang,et al."Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China".BMC PSYCHIATRY 24.1(2024):9.