Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-na?ve anxious depression: a large-scale cross-sectional study

doi:10.1007/s00702-024-02779-x

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	Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-na?ve anxious depression: a large-scale cross-sectional study
	Luo, Guoshuai 1; Wang, Shuo 1; Gou, Lei 1; Li, Cui 2; Yao, Cong 1; Jing, Yifan 1; Xuekelaiti, Zaimina 1; Li, Jie 1; Zhang, Xiang-yang 3
通讯作者	Li, Jie(jieli@tjmhc.com) ; Zhang, Xiang-yang(zhangxy@psych.ac.cn)
摘要	This study aims to investigate sex differences and risk factors for self-reported suicide attempts among Chinese Han middle-aged patients with first-episode drug-na & iuml;ve (FEDN) anxious depression (AD). A total of 1796 patients with FEDN major depressive disorder were enrolled in this study, including 341 middle-aged patients with AD. We compared the prevalence, demographics, and clinical characteristics of suicide attempts between male and female patients with FEDN middle-aged AD. We also explored the risk factors for self-reported suicide attempts in this population using binary logistic regression analysis. The male/female ratio was 91/250 and the age of onset was 51.50 +/- 4.13. Our results showed that there were no significant sex differences in the prevalence of self-reported suicide attempts in middle-aged patients with FEDN AD. However, we did find significant differences in several demographic and clinical characteristics between self-reported suicide attempters and non-suicide attempters. Moreover, severe anxiety, measured by the Hamilton Anxiety Rating Scale score, was identified as a risk factor for self-reported suicide attempts in female middle-aged AD patients. Additionally, elevated thyroid peroxidase antibody (TPOAb) levels were linked to self-reported suicide attempts in male AD patients. Our findings suggest that there are no significant sex differences in the prevalence of self-reported suicide attempts in this population, but there may be sex-specific risk factors for self-reported suicide attempts in middle-aged AD. Clinical psychiatrists need to pay attention to thyroid hormone levels in middle-aged anxious depression. This study explores sex differences in self-reported suicide attempts among Chinese Han middle-aged patients with first-episode drug-na & iuml;ve (FEDN) major depressive disorder (MDD) and anxious depression (AD).1. No significant sex differences in the prevalence of self-reported suicide attempts were observed; however, important demographic and clinical differences between suicide attempters and non-suicide attempters were identified.2. Middle-aged depression is associated with increased self-reported suicide attempts risk during ages 45-60 due to mood swings and hormonal changes.3. Psychotic symptoms in MDD patients are linked to higher suicide risk, and severe anxiety, measured by the HAMA score, is a risk factor for self-reported suicide attempts in female middle-aged AD patients.4. Elevated TPOAb levels are associated with self-reported suicide attempts in male AD patients.These findings emphasize the need for further research on sex-specific risk factors in middle-aged anxious depression to enhance suicide prevention strategies.
关键词	Suicide attempts Middle-aged Major depressive disorder Anxious depression Risk factors
	2024-05-14
语种	英语
DOI	10.1007/s00702-024-02779-x
发表期刊	JOURNAL OF NEURAL TRANSMISSION
ISSN	0300-9564
页码	12
收录类别	SCI
资助项目	National Key R&D Program of China
出版者	SPRINGER WIEN
WOS关键词	HAMILTON RATING-SCALE ; CLINICAL CHARACTERISTICS ; MAJOR DEPRESSION ; GENDER-DIFFERENCES ; DISORDER ; ANXIETY ; PREVALENCE ; ASSOCIATION ; HYPOTHYROIDISM ; TESTOSTERONE
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology ; Neurosciences
WOS记录号	WOS:001222378400002
资助机构	National Key R&D Program of China
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49350
通讯作者	Li, Jie; Zhang, Xiang-yang
作者单位	1.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Lab Biol Psychiat,Mental Hlth Ctr, Tianjin 300222, Peoples R China 2.Nanjing Tech Vocat Coll, Dept Civil Engn, 58 Huangshan Rd, Nanjing 210019, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Lincui Rd 16, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Luo, Guoshuai,Wang, Shuo,Gou, Lei,et al. Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-na?ve anxious depression: a large-scale cross-sectional study[J]. JOURNAL OF NEURAL TRANSMISSION,2024:12.
APA	Luo, Guoshuai.,Wang, Shuo.,Gou, Lei.,Li, Cui.,Yao, Cong.,...&Zhang, Xiang-yang.(2024).Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-na?ve anxious depression: a large-scale cross-sectional study.JOURNAL OF NEURAL TRANSMISSION,12.
MLA	Luo, Guoshuai,et al."Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-na?ve anxious depression: a large-scale cross-sectional study".JOURNAL OF NEURAL TRANSMISSION (2024):12.