Altered effective connectivity among face-processing systems in major depressive disorder

doi:10.1503/jpn.230123

PSYCH OpenIR

	Altered effective connectivity among face-processing systems in major depressive disorder
	Sheng, Fangrui 3,4; Wang, Yun 3,4; Li, Ruinan 3,4; Li, Xiaoya 3,4; Chen, Xiongying 3,4; Zhang, Zhifang 3,4; Liu, Rui 3,4; Zhang, Ling 1,2,3,4,5; Zhou, Yuan 3,4,6,7; Wang, Gang 1,2,3,4,5
通讯作者	Zhang, Ling(13661341082@163.com) ; Zhou, Yuan(zhouyuan@psych.ac.cn) ; Wang, Gang(gangwangdoc@ccmu.edu.cn)
摘要	Background: Neuroimaging studies have revealed abnormal functional interaction during the processing of emotional faces in patients with major depressive disorder (MDD), thereby enhancing our comprehension of the pathophysiology of MDD. However, it is unclear whether there is abnormal directional interaction among face-processing systems in patients with MDD.Methods: A group of patients with MDD and a healthy control group underwent a face-matching task during functional magnetic resonance imaging. Dynamic causal modelling (DCM) analysis was used to investigate effective connectivity between 7 regions in the face-processing systems. We used a Parametric Empirical Bayes model to compare effective connectivity between patients with MDD and controls.Results: We included 48 patients and 44 healthy controls in our analyses. Both groups showed higher accuracy and faster reaction time in the shape-matching condition than in the face-matching condition. However, no significant behavioural or brain activation differences were found between the groups. Using DCM, we found that, compared with controls, patients with MDD showed decreased self-connection in the right dorsolateral prefrontal cortex (DLPFC), amygdala, and fusiform face area (FFA) across task conditions; increased intrinsic connectivity from the right amygdala to the bilateral DLPFC, right FFA, and left amygdala, suggesting an increased intrinsic connectivity centred in the amygdala in the right side of the face-processing systems; both increased and decreased positive intrinsic connectivity in the left side of the face-processing systems; and comparable task modulation effect on connectivity.Limitations: Our study did not include longitudinal neuroimaging data, and there was limited region of interest selection in the DCM analysis.Conclusion: Our findings provide evidence for a complex pattern of alterations in the face-processing systems in patients with MDD, potentially involving the right amygdala to a greater extent. The results confirm some previous findings and highlight the crucial role of the regions on both sides of face-processing systems in the pathophysiology of MDD.
	2024
语种	英语
DOI	10.1503/jpn.230123
发表期刊	JOURNAL OF PSYCHIATRY & NEUROSCIENCE
ISSN	1180-4882
卷号	49 期号:3 页码:E145-E156
收录类别	SCI
资助项目	Beijing Municipal Science & Technology Commission
出版者	CMA-CANADIAN MEDICAL ASSOC
WOS关键词	ANTIDEPRESSANT TREATMENT ; PREFRONTAL CORTEX ; EMOTIONAL FACES ; AMYGDALA HYPERACTIVATION ; UNIPOLAR DEPRESSION ; FACIAL EXPRESSIONS ; NEURAL RESPONSE ; BOTTOM-UP ; STIMULI ; ACTIVATION
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Neurosciences ; Psychiatry
WOS记录号	WOS:001225949700001
资助机构	Beijing Municipal Science & Technology Commission
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/49354
通讯作者	Zhang, Ling; Zhou, Yuan; Wang, Gang
作者单位	1.Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China 2.Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China 3.Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China 4.Capital Med Univ, Beijing Anding Hosp, Natl Ctr Mental Disorders, Beijing, Peoples R China 5.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China 6.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Sheng, Fangrui,Wang, Yun,Li, Ruinan,et al. Altered effective connectivity among face-processing systems in major depressive disorder[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2024,49(3):E145-E156.
APA	Sheng, Fangrui.,Wang, Yun.,Li, Ruinan.,Li, Xiaoya.,Chen, Xiongying.,...&Wang, Gang.(2024).Altered effective connectivity among face-processing systems in major depressive disorder.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,49(3),E145-E156.
MLA	Sheng, Fangrui,et al."Altered effective connectivity among face-processing systems in major depressive disorder".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 49.3(2024):E145-E156.