PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Thesis Advisor管林初
Degree Grantor中国科学院心理研究所
Place of Conferral中国科学院心理研究所
Degree Discipline心理学
Keyword樟柳碱 石衫碱甲 Morris水迷津 认知策略 学习和记忆 慢性微电极技术 海马神经元活动


Other Abstract

Two experiments were designed to examine the role of the cholinergic agents, anisodine and huperzine A, and related mechanisms. In experiment 1, the effects of anisodine and huperzine A on rat performance in Morris water maze were observed. It was found that the drugs injected before daily training had significant effect on performance of place navigation task and transfer test, while the drugs injected after daily training, before retest and overtraining had no such effect. the results indicated that the drugs, which only have effects on reference memory related to cognitive mapping strategy, may mediate the acquisition process of memory. In experiment 2, the spontaneous hippocampol neuronal activities and the effects of the drugs on them in awake rabbits were observed. The results showed that anisodine had significant inhibitory effect on the activities, the opposite effect was found in huperzine A. Furthermore, sensory stimulation and administration of huperzine A have similar effects. It was sujested that hipppocampus be directly relavent to transmission of information to memory storage system, in which the role of central cholinergic system is critical.

Document Type学位论文
Recommended Citation
GB/T 7714
翁旭初. 樟柳碱和石杉碱甲对学习和记忆的影响及其有关机制的研究[D]. 中国科学院心理研究所. 中国科学院心理研究所,1992.
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