中国科学院心理研究所机构知识库

本研究用一种新异刺激糖精水(SAC)作为条件刺激，用腹腔注射一种蛋白质抗原卵清蛋白(OVA)作为非条件刺激配对呈现给大鼠，以建立条件反射。在实验1中，给受过条件反射训练的条件刺激组大鼠再次进行条件刺激后，既没有发现明显的条件反射性免疫调节效应，也没有发现行为性条件反射的建立;在实验2中，当再次给条件刺激组大鼠进行条件刺激时，再次注射微量的OVA与对照组动物相比，条件刺激组大鼠抗体水平明显增高;条件刺激组动物仍没有建立行为性条件反射。因此本研究结果表明:

1.再次呈现条件刺激时再次注射微量同种抗原可使中枢神经系统更好的发挥对免疫功能的调节作用

2.条件反射性免疫效应的获得不必伴有行为条件反射的建立。

In this research program, experimental rats were conditioned by exposure to a saccharin solution, the conditioned stimulus (CS), paired with an intraperitoneal (ip) injection of ovalbumin (OVA), the unconditioned stimulus （UCS). In Experiment 1，the conditioned immunomodulation effect was not detected after reexposed the conditioned animal to the CS alone after one CS-UCS pairing. The behavioral conditioned response was also not established. However, in Experiment 2, an enhancement of anti-OVA IgG production (compared with the control groups) was observed when conditioned rats were reexposed to the CS in the context of reexposure to a low dose of the same antigen as the UCS, even though the behavioral conditioned response was still not established. These data showed that, (1) Reexposure to a low dose of the same antigen as the UCS at the time of reexposure to the CS was helpful for the central nerves system to regulate the function;(2) The conditioned immunmodulation could be achieved without the establishment of the behavioral conditioning response.