2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells

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	2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells
	Guo, Jian-You; Huo, Hai-Ru ; Yang, Yuan-Xiao ; Li, Cang-Hai ; Liu, Hong-Bin ; Zhao, Bao-Sheng ; Li, Lan-Fang ; Ma, Yue-Ying ; Guo, Shu-Ying ; Jiang, Ting-Liang ; Hai-Ru HUO
摘要	Prostaglandin E-2 (PGE(2)) works as a common final mediator of the febrile. Guizhi-Tang, one of the most famous traditional Chinese medical formula used to treat influenza, common cold and other pyretic conditions, was previously reported to reduce the production of PGE(2) in rats. 2-Methoxycinnamaldehyde is a principle compound isolated from Guizhi-Tang. The aim of the present study was to investigate the effects of 2-methoxycinnamaldehyde on PGE(2) production of rat cerebral endothelial cells (CECs). 2-Methoxycinnamaldehyde dose-dependently inhibited interleukin (IL)-1 beta-induced PGE(2) production in CECs with IC50 values of 174 mu m. IL-1 beta stimulation increased the protein, activity and mRNA expression of cyclooxygenase (COX)-2 but not COX-1. 2-Methoxycinnamaldehyde reduced IL-1 beta-induced protein and activity of COX-2, but did not influence the COX-2 mRNA expression. Our results show that prostaglandin production in CECs during stimulated conditions is sensitive to inhibition by 2-methoxycinnamaldehyde and suggest that 2-methoxycinnamaldehyde may reduce COX-2 protein level and activity but not COX-2 mRNA.; Prostaglandin E-2 (PGE(2)) works as a common final mediator of the febrile. Guizhi-Tang, one of the most famous traditional Chinese medical formula used to treat influenza, common cold and other pyretic conditions, was previously reported to reduce the production of PGE(2) in rats. 2-Methoxycinnamaldehyde is a principle compound isolated from Guizhi-Tang. The aim of the present study was to investigate the effects of 2-methoxycinnamaldehyde on PGE(2) production of rat cerebral endothelial cells (CECs). 2-Methoxycinnamaldehyde dose-dependently inhibited interleukin (IL)-1 beta-induced PGE(2) production in CECs with IC50 values of 174 mu m. IL-1 beta stimulation increased the protein, activity and mRNA expression of cyclooxygenase (COX)-2 but not COX-1. 2-Methoxycinnamaldehyde reduced IL-1 beta-induced protein and activity of COX-2, but did not influence the COX-2 mRNA expression. Our results show that prostaglandin production in CECs during stimulated conditions is sensitive to inhibition by 2-methoxycinnamaldehyde and suggest that 2-methoxycinnamaldehyde may reduce COX-2 protein level and activity but not COX-2 mRNA.
关键词	2-methoxycinnamaldehyde rat cerebral endothelial cell interleukin-1 beta cyclooxygenase prostaglandin E-2
学科领域	生理心理学/生物心理学
	2006-11-01
语种	英语
发表期刊	BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN	0918-6158
卷号	29 期号:11 页码:2214-2221
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000242457300011
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5111
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Hai-Ru HUO
作者单位	1.Chinese Acad Chinese Med Sci, Inst Chinese Materia Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 3.Chinese Med Univ, Hangzhou 310053, Peoples R China
推荐引用方式 GB/T 7714	Guo, Jian-You,Huo, Hai-Ru,Yang, Yuan-Xiao,et al. 2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2006,29(11):2214-2221.
APA	Guo, Jian-You.,Huo, Hai-Ru.,Yang, Yuan-Xiao.,Li, Cang-Hai.,Liu, Hong-Bin.,...&Hai-Ru HUO.(2006).2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,29(11),2214-2221.
MLA	Guo, Jian-You,et al."2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 29.11(2006):2214-2221.

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