2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells
Guo, Jian-You; Huo, Hai-Ru; Yang, Yuan-Xiao; Li, Cang-Hai; Liu, Hong-Bin; Zhao, Bao-Sheng; Li, Lan-Fang; Ma, Yue-Ying; Guo, Shu-Ying; Jiang, Ting-Liang; Hai-Ru HUO
2006-11-01
发表期刊BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN0918-6158
文章类型Article
卷号29期号:11页码:2214-2221
摘要Prostaglandin E-2 (PGE(2)) works as a common final mediator of the febrile. Guizhi-Tang, one of the most famous traditional Chinese medical formula used to treat influenza, common cold and other pyretic conditions, was previously reported to reduce the production of PGE(2) in rats. 2-Methoxycinnamaldehyde is a principle compound isolated from Guizhi-Tang. The aim of the present study was to investigate the effects of 2-methoxycinnamaldehyde on PGE(2) production of rat cerebral endothelial cells (CECs). 2-Methoxycinnamaldehyde dose-dependently inhibited interleukin (IL)-1 beta-induced PGE(2) production in CECs with IC50 values of 174 mu m. IL-1 beta stimulation increased the protein, activity and mRNA expression of cyclooxygenase (COX)-2 but not COX-1. 2-Methoxycinnamaldehyde reduced IL-1 beta-induced protein and activity of COX-2, but did not influence the COX-2 mRNA expression. Our results show that prostaglandin production in CECs during stimulated conditions is sensitive to inhibition by 2-methoxycinnamaldehyde and suggest that 2-methoxycinnamaldehyde may reduce COX-2 protein level and activity but not COX-2 mRNA.; Prostaglandin E-2 (PGE(2)) works as a common final mediator of the febrile. Guizhi-Tang, one of the most famous traditional Chinese medical formula used to treat influenza, common cold and other pyretic conditions, was previously reported to reduce the production of PGE(2) in rats. 2-Methoxycinnamaldehyde is a principle compound isolated from Guizhi-Tang. The aim of the present study was to investigate the effects of 2-methoxycinnamaldehyde on PGE(2) production of rat cerebral endothelial cells (CECs). 2-Methoxycinnamaldehyde dose-dependently inhibited interleukin (IL)-1 beta-induced PGE(2) production in CECs with IC50 values of 174 mu m. IL-1 beta stimulation increased the protein, activity and mRNA expression of cyclooxygenase (COX)-2 but not COX-1. 2-Methoxycinnamaldehyde reduced IL-1 beta-induced protein and activity of COX-2, but did not influence the COX-2 mRNA expression. Our results show that prostaglandin production in CECs during stimulated conditions is sensitive to inhibition by 2-methoxycinnamaldehyde and suggest that 2-methoxycinnamaldehyde may reduce COX-2 protein level and activity but not COX-2 mRNA.
关键词2-methoxycinnamaldehyde rat cerebral endothelial cell interleukin-1 beta cyclooxygenase prostaglandin E-2
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000242457300011
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5111
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Hai-Ru HUO
作者单位1.Chinese Acad Chinese Med Sci, Inst Chinese Materia Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
3.Chinese Med Univ, Hangzhou 310053, Peoples R China
推荐引用方式
GB/T 7714
Guo, Jian-You,Huo, Hai-Ru,Yang, Yuan-Xiao,et al. 2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2006,29(11):2214-2221.
APA Guo, Jian-You.,Huo, Hai-Ru.,Yang, Yuan-Xiao.,Li, Cang-Hai.,Liu, Hong-Bin.,...&Hai-Ru HUO.(2006).2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,29(11),2214-2221.
MLA Guo, Jian-You,et al."2-methoxycinnamaldehyde reduces IL-1 beta-induced prostaglandin production in rat cerebral endothelial cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 29.11(2006):2214-2221.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Guo-2006-2-methoxyci(1092KB) 限制开放--浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Guo, Jian-You]的文章
[Huo, Hai-Ru]的文章
[Yang, Yuan-Xiao]的文章
百度学术
百度学术中相似的文章
[Guo, Jian-You]的文章
[Huo, Hai-Ru]的文章
[Yang, Yuan-Xiao]的文章
必应学术
必应学术中相似的文章
[Guo, Jian-You]的文章
[Huo, Hai-Ru]的文章
[Yang, Yuan-Xiao]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Guo-2006-2-methoxycinnamaldeh.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。