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A comparison between spontaneous electroencephalographic activities induced by morphine and morphine-related environment in rats
Zuo, Yan-Fang; Wang, Jin-Yan; Chen, Ji-Huan; Qiao, Zhi-Mei; Han, Ji-Sheng; Cui, Cai-Lian; Luo, Fei; C. L. Cui; F. Luo
2007-03-09
Source PublicationBRAIN RESEARCH
ISSN0006-8993
SubtypeArticle
Volume1136Issue:1Pages:88-101
AbstractPrevious studies demonstrated that drug cues could elicit drug-like or withdrawal-like effect, both subjectively and physiologically. However, few studies have compared the central activities induced by a drug-related environment and the drug itself. The aim of this study was to observe and compare electroencephalographic (EEG) changes induced by acute morphine administration and by the morphine-related environment. EEG activities were recorded via twelve skull electrodes scattered on the left and right cortex in conscious, freely moving rats, either after acute morphine administration or after successful training of conditioned place preference. Acute administration of morphine (0.1, 0.5, 1, 5, 10,20 mg/kg, i. p.) produced an increase in absolute EEG power in the delta, theta, alphal, alpha2, betal, and beta2 bands, as well as a decrease in the gamma band. Topographic mapping revealed a maximal increase in the lateral leads in the theta band and a maximal change in the centrofrontal region in the remaining bands. After place conditioning training, the morphine-related environment induced a diffuse decrease in absolute power in the delta, theta, alphal, alpha2, betal, and beta2 bands, which was opposite to the changes induced by acute morphine administration. In addition, the changes in relative power induced by the two situations also diverged. These results indicate that the central mechanisms underlying the motivation of morphine-induced place preference may be somehow different from those underlying the reward effects produced by acute morphine administration.; Previous studies demonstrated that drug cues could elicit drug-like or withdrawal-like effect, both subjectively and physiologically. However, few studies have compared the central activities induced by a drug-related environment and the drug itself. The aim of this study was to observe and compare electroencephalographic (EEG) changes induced by acute morphine administration and by the morphine-related environment. EEG activities were recorded via twelve skull electrodes scattered on the left and right cortex in conscious, freely moving rats, either after acute morphine administration or after successful training of conditioned place preference. Acute administration of morphine (0.1, 0.5, 1, 5, 10,20 mg/kg, i. p.) produced an increase in absolute EEG power in the delta, theta, alphal, alpha2, betal, and beta2 bands, as well as a decrease in the gamma band. Topographic mapping revealed a maximal increase in the lateral leads in the theta band and a maximal change in the centrofrontal region in the remaining bands. After place conditioning training, the morphine-related environment induced a diffuse decrease in absolute power in the delta, theta, alphal, alpha2, betal, and beta2 bands, which was opposite to the changes induced by acute morphine administration. In addition, the changes in relative power induced by the two situations also diverged. These results indicate that the central mechanisms underlying the motivation of morphine-induced place preference may be somehow different from those underlying the reward effects produced by acute morphine administration. (c) 2006 Elsevier B.V. All rights reserved.
Keywordmorphine opioid addiction conditioned place preference drug-seeking electroencephalogram
Subject Area生理心理学/生物心理学
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000244882500009
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5117
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorC. L. Cui; F. Luo
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 10083, Peoples R China
Recommended Citation
GB/T 7714
Zuo, Yan-Fang,Wang, Jin-Yan,Chen, Ji-Huan,et al. A comparison between spontaneous electroencephalographic activities induced by morphine and morphine-related environment in rats[J]. BRAIN RESEARCH,2007,1136(1):88-101.
APA Zuo, Yan-Fang.,Wang, Jin-Yan.,Chen, Ji-Huan.,Qiao, Zhi-Mei.,Han, Ji-Sheng.,...&F. Luo.(2007).A comparison between spontaneous electroencephalographic activities induced by morphine and morphine-related environment in rats.BRAIN RESEARCH,1136(1),88-101.
MLA Zuo, Yan-Fang,et al."A comparison between spontaneous electroencephalographic activities induced by morphine and morphine-related environment in rats".BRAIN RESEARCH 1136.1(2007):88-101.
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